
A practical model for economic evaluation of tissue-engineered therapies.
UNLABELLED: Tissue-engineered therapies are being developed across virtually all fields of medicine. Some of these therapies are already in clinical use, while others are still in clinical trials or the experimental phase. Most initial studies in the evaluation of new therapies focus on demonstration of clinical efficacy. However, cost considerations or economic viability are just as important. Many tissue-engineered therapies have failed to be impactful because of shortcomings in economic competitiveness, rather than clinical efficacy. Furthermore, such economic viability studies should be performed early in the process of development, before significant investment has been made. Cost-minimization analysis combined with sensitivity analysis is a useful model for the economic evaluation of new tissue-engineered therapies. The analysis can be performed early in the development process, and can provide valuable information to guide further investment and research. The utility of the model is illustrated with the practical real-world example of tissue-engineered constructs for corneal endothelial transplantation. CONFLICT OF INTEREST: The authors have declared no conflicts of interest for this article.
Duke Scholars
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- Tissue Engineering
- Models, Biological
- Humans
- Endothelial Cells
- Corneal Diseases
- 3101 Biochemistry and cell biology
- 1199 Other Medical and Health Sciences
- 1103 Clinical Sciences
Citation

Published In
DOI
EISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Tissue Engineering
- Models, Biological
- Humans
- Endothelial Cells
- Corneal Diseases
- 3101 Biochemistry and cell biology
- 1199 Other Medical and Health Sciences
- 1103 Clinical Sciences