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Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore.

Publication ,  Journal Article
Wong, CW; Liao, J; Cheung, GC; Khor, CC; Vithana, EN; Wang, JJ; Mitchell, P; Aung, T; Wong, TY; Cheng, C-Y
Published in: PLoS One
2015

AIMS: To determine the differential effects of genetic polymorphism in CFH and ARMS2 on risk of age-related macular degeneration (AMD) between phakic vs. pseudophakic/aphakic eyes. METHODS: 9,529 eyes of 4,918 participants from the Singapore Malay Eye Study and Singapore Indian Eye Study were analyzed. Participants had detailed eye examinations, including slit-lamp examinations and dilated fundus photography. AMD grading was performed according to the Wisconsin age-related maculopathy grading system. Lens status was defined. Single nucleotide polymorphisms (SNPs) rs10801555 (Y402H) within CFH and rs3750847 in ARMS2 were assessed. The main outcome measure was early AMD or any AMD. RESULTS: No significant associations between the CFH Y402H genotypes and early AMD were found in phakic individuals. In contrast, among pseudophakic/aphakic individuals, the CFH Y402H risk genotypes were significantly associated with higher odds of early AMD, with an OR of 1.57 (95% CI: 1.07-2.29) for GA genotype and 2.40 (95% CI: 1.25-4.61) for AA genotype, compared to those with GG genotype. There was significant interaction between pseudophakic/aphakic status and CFH Y402H variant on risk of early AMD (p = 0.037), adjusting for age, gender, and the first 5 genetic principal components. No significant interaction was found between lens status and ARMS2 rs3750847. CONCLUSIONS: CFH genetic polymorphism and pseudophakic/aphakic status may have a potential synergistic effect on early AMD, suggesting roles for the complement system and related pathways in the pathogenesis of AMD in eyes after cataract surgery.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

3

Start / End Page

e0119570

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Proteins
  • Polymorphism, Single Nucleotide
  • Phakic Intraocular Lenses
  • Odds Ratio
  • Middle Aged
  • Male
  • Macular Degeneration
  • Lens, Crystalline
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wong, C. W., Liao, J., Cheung, G. C., Khor, C. C., Vithana, E. N., Wang, J. J., … Cheng, C.-Y. (2015). Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. PLoS One, 10(3), e0119570. https://doi.org/10.1371/journal.pone.0119570
Wong, Chee Wai, Jiemin Liao, Gemmy C. Cheung, Chiea Chuen Khor, Eranga N. Vithana, Jie Jin Wang, Paul Mitchell, Tin Aung, Tien Y. Wong, and Ching-Yu Cheng. “Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore.PLoS One 10, no. 3 (2015): e0119570. https://doi.org/10.1371/journal.pone.0119570.
Wong, Chee Wai, et al. “Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore.PLoS One, vol. 10, no. 3, 2015, p. e0119570. Pubmed, doi:10.1371/journal.pone.0119570.
Wong CW, Liao J, Cheung GC, Khor CC, Vithana EN, Wang JJ, Mitchell P, Aung T, Wong TY, Cheng C-Y. Lens status influences the association between CFH polymorphisms and age-related macular degeneration: findings from two population-based studies in Singapore. PLoS One. 2015;10(3):e0119570.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

3

Start / End Page

e0119570

Location

United States

Related Subject Headings

  • Singapore
  • Risk Factors
  • Proteins
  • Polymorphism, Single Nucleotide
  • Phakic Intraocular Lenses
  • Odds Ratio
  • Middle Aged
  • Male
  • Macular Degeneration
  • Lens, Crystalline