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Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test.

Publication ,  Journal Article
Sellers, KK; Mellin, JM; Lustenberger, CM; Boyle, MR; Lee, WH; Peterchev, AV; Fröhlich, F
Published in: Behav Brain Res
September 1, 2015

Transcranial direct current stimulation (tDCS) modulates excitability of motor cortex. However, there is conflicting evidence about the efficacy of this non-invasive brain stimulation modality to modulate performance on cognitive tasks. Previous work has tested the effect of tDCS on specific facets of cognition and executive processing. However, no randomized, double-blind, sham-controlled study has looked at the effects of tDCS on a comprehensive battery of cognitive processes. The objective of this study was to test if tDCS had an effect on performance on a comprehensive assay of cognitive processes, a standardized intelligence quotient (IQ) test. The study consisted of two substudies and followed a double-blind, between-subjects, sham-controlled design. In total, 41 healthy adult participants were included in the final analysis. These participants completed the Wechsler Adult Intelligence Scale, Fourth Edition (WAIS-IV) as a baseline measure. At least one week later, participants in substudy 1 received either bilateral tDCS (anodes over both F4 and F3, cathode over Cz, 2 mA at each anode for 20 min) or active sham tDCS (2 mA for 40 s), and participants in substudy 2 received either right or left tDCS (anode over either F4 or F3, cathode over Cz, 2 mA for 20 min). In both studies, the WAIS-IV was immediately administered following stimulation to assess for performance differences induced by bilateral and unilateral tDCS. Compared to sham stimulation, right, left, and bilateral tDCS reduced improvement between sessions on Full Scale IQ and the Perceptual Reasoning Index. This demonstration that frontal tDCS selectively degraded improvement on specific metrics of the WAIS-IV raises important questions about the often proposed role of tDCS in cognitive enhancement.

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Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

September 1, 2015

Volume

290

Start / End Page

32 / 44

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Wechsler Scales
  • Transcranial Direct Current Stimulation
  • Thinking
  • Prefrontal Cortex
  • Practice, Psychological
  • Perception
  • Neurology & Neurosurgery
  • Male
  • Intelligence
 

Citation

APA
Chicago
ICMJE
MLA
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Sellers, K. K., Mellin, J. M., Lustenberger, C. M., Boyle, M. R., Lee, W. H., Peterchev, A. V., & Fröhlich, F. (2015). Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test. Behav Brain Res, 290, 32–44. https://doi.org/10.1016/j.bbr.2015.04.031
Sellers, Kristin K., Juliann M. Mellin, Caroline M. Lustenberger, Michael R. Boyle, Won Hee Lee, Angel V. Peterchev, and Flavio Fröhlich. “Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test.Behav Brain Res 290 (September 1, 2015): 32–44. https://doi.org/10.1016/j.bbr.2015.04.031.
Sellers KK, Mellin JM, Lustenberger CM, Boyle MR, Lee WH, Peterchev AV, et al. Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test. Behav Brain Res. 2015 Sep 1;290:32–44.
Sellers, Kristin K., et al. “Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test.Behav Brain Res, vol. 290, Sept. 2015, pp. 32–44. Pubmed, doi:10.1016/j.bbr.2015.04.031.
Sellers KK, Mellin JM, Lustenberger CM, Boyle MR, Lee WH, Peterchev AV, Fröhlich F. Transcranial direct current stimulation (tDCS) of frontal cortex decreases performance on the WAIS-IV intelligence test. Behav Brain Res. 2015 Sep 1;290:32–44.

Published In

Behav Brain Res

DOI

EISSN

1872-7549

Publication Date

September 1, 2015

Volume

290

Start / End Page

32 / 44

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Wechsler Scales
  • Transcranial Direct Current Stimulation
  • Thinking
  • Prefrontal Cortex
  • Practice, Psychological
  • Perception
  • Neurology & Neurosurgery
  • Male
  • Intelligence