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Identification of new susceptibility loci for IgA nephropathy in Han Chinese.

Publication ,  Journal Article
Li, M; Foo, J-N; Wang, J-Q; Low, H-Q; Tang, X-Q; Toh, K-Y; Yin, P-R; Khor, C-C; Goh, Y-F; Irwan, ID; Xu, R-C; Andiappan, AK; Bei, J-X; Ye, K ...
Published in: Nat Commun
June 1, 2015

IgA nephropathy (IgAN) is one of the most common primary glomerulonephritis. Previously identified genome-wide association study (GWAS) loci explain only a fraction of disease risk. To identify novel susceptibility loci in Han Chinese, we conduct a four-stage GWAS comprising 8,313 cases and 19,680 controls. Here, we show novel associations at ST6GAL1 on 3q27.3 (rs7634389, odds ratio (OR)=1.13, P=7.27 × 10(-10)), ACCS on 11p11.2 (rs2074038, OR=1.14, P=3.93 × 10(-9)) and ODF1-KLF10 on 8q22.3 (rs2033562, OR=1.13, P=1.41 × 10(-9)), validate a recently reported association at ITGAX-ITGAM on 16p11.2 (rs7190997, OR=1.22, P=2.26 × 10(-19)), and identify three independent signals within the DEFA locus (rs2738058, P=1.15 × 10(-19); rs12716641, P=9.53 × 10(-9); rs9314614, P=4.25 × 10(-9), multivariate association). The risk variants on 3q27.3 and 11p11.2 show strong association with mRNA expression levels in blood cells while allele frequencies of the risk variants within ST6GAL1, ACCS and DEFA correlate with geographical variation in IgAN prevalence. Our findings expand our understanding on IgAN genetic susceptibility and provide novel biological insights into molecular mechanisms underlying IgAN.

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Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 1, 2015

Volume

6

Start / End Page

7270

Location

England

Related Subject Headings

  • Young Adult
  • Sialyltransferases
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Middle Aged
  • Male
  • Lyases
  • Kruppel-Like Transcription Factors
  • Humans
  • Heat-Shock Proteins
 

Citation

APA
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ICMJE
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Li, M., Foo, J.-N., Wang, J.-Q., Low, H.-Q., Tang, X.-Q., Toh, K.-Y., … Liu, J.-J. (2015). Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat Commun, 6, 7270. https://doi.org/10.1038/ncomms8270
Li, Ming, Jia-Nee Foo, Jin-Quan Wang, Hui-Qi Low, Xue-Qing Tang, Kai-Yee Toh, Pei-Ran Yin, et al. “Identification of new susceptibility loci for IgA nephropathy in Han Chinese.Nat Commun 6 (June 1, 2015): 7270. https://doi.org/10.1038/ncomms8270.
Li M, Foo J-N, Wang J-Q, Low H-Q, Tang X-Q, Toh K-Y, et al. Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat Commun. 2015 Jun 1;6:7270.
Li, Ming, et al. “Identification of new susceptibility loci for IgA nephropathy in Han Chinese.Nat Commun, vol. 6, June 2015, p. 7270. Pubmed, doi:10.1038/ncomms8270.
Li M, Foo J-N, Wang J-Q, Low H-Q, Tang X-Q, Toh K-Y, Yin P-R, Khor C-C, Goh Y-F, Irwan ID, Xu R-C, Andiappan AK, Bei J-X, Rotzschke O, Chen M-H, Cheng C-Y, Sun L-D, Jiang G-R, Wong T-Y, Lin H-L, Aung T, Liao Y-H, Saw S-M, Ye K, Ebstein RP, Chen Q-K, Shi W, Chew S-H, Chen J, Zhang F-R, Li S-P, Xu G, Shyong Tai E, Wang L, Chen N, Zhang X-J, Zeng Y-X, Zhang H, Liu Z-H, Yu X-Q, Liu J-J. Identification of new susceptibility loci for IgA nephropathy in Han Chinese. Nat Commun. 2015 Jun 1;6:7270.

Published In

Nat Commun

DOI

EISSN

2041-1723

Publication Date

June 1, 2015

Volume

6

Start / End Page

7270

Location

England

Related Subject Headings

  • Young Adult
  • Sialyltransferases
  • Polymorphism, Single Nucleotide
  • Odds Ratio
  • Middle Aged
  • Male
  • Lyases
  • Kruppel-Like Transcription Factors
  • Humans
  • Heat-Shock Proteins