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Body mass index and preclinical kidney disease in Indian adults aged 40 years and above without chronic kidney disease.

Publication ,  Journal Article
Sabanayagam, C; Wong, TY; Liao, J; Sethi, S; Teo, BW
Published in: Clin Exp Nephrol
December 2014

BACKGROUND: Obesity is associated with diabetes and hypertension, two major risk factors for chronic kidney disease (CKD). Recently, it has been shown that obesity is associated with preclinical kidney disease defined by elevated levels of cystatin C among those without CKD in US adults. However, the association of obesity with cystatin C is not known in industrialized Asian populations. METHODS: We examined 2,052 Indian adults aged 40-80 years in Singapore who were free of CKD defined as a serum creatinine-based estimated glomerular filtration rate (eGFRcr) <60 mL/min/1.73 m(2) and/or the presence of microalbuminuria. Body mass index (BMI) values were categorized into normal (18.5-24.9), overweight (25-29.9) and obese (≥30 kg/m(2)). Elevated serum cystatin C was defined as cystatin C ≥1 mg/L. RESULTS: Overweight and obesity were significantly associated with elevated levels of cystatin C after adjusting for potential confounders including diabetes and hypertension and eGFRcr. Compared to those with normal weight, the odds ratio (95 % confidence interval) of elevated cystatin C was 1.49 (1.17-1.88) for overweight and 3.20 (2.33-4.39) for obese. This association was consistently present when BMI was analyzed as a continuous variable and also in subgroups of men, women and in those without diabetes mellitus or hypertension. CONCLUSIONS: Higher BMI levels are associated with preclinical kidney disease in Indian adults aged 40 years and above without CKD.

Duke Scholars

Published In

Clin Exp Nephrol

DOI

EISSN

1437-7799

Publication Date

December 2014

Volume

18

Issue

6

Start / End Page

919 / 924

Location

Japan

Related Subject Headings

  • Urology & Nephrology
  • Singapore
  • Risk Factors
  • Renal Insufficiency, Chronic
  • Overweight
  • Obesity
  • Middle Aged
  • Male
  • Kidney
  • India
 

Citation

APA
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ICMJE
MLA
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Sabanayagam, C., Wong, T. Y., Liao, J., Sethi, S., & Teo, B. W. (2014). Body mass index and preclinical kidney disease in Indian adults aged 40 years and above without chronic kidney disease. Clin Exp Nephrol, 18(6), 919–924. https://doi.org/10.1007/s10157-014-0945-6
Sabanayagam, Charumathi, Tien Yin Wong, Jiemin Liao, Sunil Sethi, and Boon Wee Teo. “Body mass index and preclinical kidney disease in Indian adults aged 40 years and above without chronic kidney disease.Clin Exp Nephrol 18, no. 6 (December 2014): 919–24. https://doi.org/10.1007/s10157-014-0945-6.
Sabanayagam C, Wong TY, Liao J, Sethi S, Teo BW. Body mass index and preclinical kidney disease in Indian adults aged 40 years and above without chronic kidney disease. Clin Exp Nephrol. 2014 Dec;18(6):919–24.
Sabanayagam, Charumathi, et al. “Body mass index and preclinical kidney disease in Indian adults aged 40 years and above without chronic kidney disease.Clin Exp Nephrol, vol. 18, no. 6, Dec. 2014, pp. 919–24. Pubmed, doi:10.1007/s10157-014-0945-6.
Sabanayagam C, Wong TY, Liao J, Sethi S, Teo BW. Body mass index and preclinical kidney disease in Indian adults aged 40 years and above without chronic kidney disease. Clin Exp Nephrol. 2014 Dec;18(6):919–924.
Journal cover image

Published In

Clin Exp Nephrol

DOI

EISSN

1437-7799

Publication Date

December 2014

Volume

18

Issue

6

Start / End Page

919 / 924

Location

Japan

Related Subject Headings

  • Urology & Nephrology
  • Singapore
  • Risk Factors
  • Renal Insufficiency, Chronic
  • Overweight
  • Obesity
  • Middle Aged
  • Male
  • Kidney
  • India