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Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia.

Publication ,  Journal Article
Kohrt, BA; Worthman, CM; Ressler, KJ; Mercer, KB; Upadhaya, N; Koirala, S; Nepal, MK; Sharma, VD; Binder, EB
Published in: Int Rev Psychiatry
2015

Despite increased attention to global mental health, psychiatric genetic research has been dominated by studies in high-income countries, especially with populations of European descent. The objective of this study was to assess single nucleotide polymorphisms (SNPs) in the FKBP5 gene in a population living in South Asia. Among adults in Nepal, depression was assessed with the Beck Depression Inventory (BDI), post-traumatic stress disorder (PTSD) with the PTSD Checklist-Civilian Version (PCL-C), and childhood maltreatment with the Childhood Trauma Questionnaire (CTQ). FKBP5 SNPs were genotyped for 682 participants. Cortisol awakening response (CAR) was assessed in a subsample of 118 participants over 3 days. The FKBP5 tag-SNP rs9296158 showed a main effect on depressive symptoms (p = 0.03). Interaction of rs9296158 and childhood maltreatment predicted adult depressive symptoms (p = 0.02) but not PTSD. Childhood maltreatment associated with endocrine response in individuals homozygous for the A allele, demonstrated by a negative CAR and overall hypocortisolaemia in the rs9296158 AA genotype and childhood maltreatment group (p < 0.001). This study replicated findings related to FKBP5 and depression but not PTSD. Gene-environment studies should take differences in prevalence and cultural significance of phenotypes and exposures into account when interpreting cross-cultural findings.

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Published In

Int Rev Psychiatry

DOI

EISSN

1369-1627

Publication Date

2015

Volume

27

Issue

3

Start / End Page

180 / 196

Location

England

Related Subject Headings

  • Tacrolimus Binding Proteins
  • Stress Disorders, Post-Traumatic
  • Social Class
  • Psychiatry
  • Nepal
  • Middle Aged
  • Male
  • Hydrocortisone
  • Humans
  • Gene-Environment Interaction
 

Citation

APA
Chicago
ICMJE
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Kohrt, B. A., Worthman, C. M., Ressler, K. J., Mercer, K. B., Upadhaya, N., Koirala, S., … Binder, E. B. (2015). Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia. Int Rev Psychiatry, 27(3), 180–196. https://doi.org/10.3109/09540261.2015.1020052
Kohrt, Brandon A., Carol M. Worthman, Kerry J. Ressler, Kristina B. Mercer, Nawaraj Upadhaya, Suraj Koirala, Mahendra K. Nepal, Vidya Dev Sharma, and Elisabeth B. Binder. “Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia.Int Rev Psychiatry 27, no. 3 (2015): 180–96. https://doi.org/10.3109/09540261.2015.1020052.
Kohrt, Brandon A., et al. “Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia.Int Rev Psychiatry, vol. 27, no. 3, 2015, pp. 180–96. Pubmed, doi:10.3109/09540261.2015.1020052.
Kohrt BA, Worthman CM, Ressler KJ, Mercer KB, Upadhaya N, Koirala S, Nepal MK, Sharma VD, Binder EB. Cross-cultural gene- environment interactions in depression, post-traumatic stress disorder, and the cortisol awakening response: FKBP5 polymorphisms and childhood trauma in South Asia. Int Rev Psychiatry. 2015;27(3):180–196.

Published In

Int Rev Psychiatry

DOI

EISSN

1369-1627

Publication Date

2015

Volume

27

Issue

3

Start / End Page

180 / 196

Location

England

Related Subject Headings

  • Tacrolimus Binding Proteins
  • Stress Disorders, Post-Traumatic
  • Social Class
  • Psychiatry
  • Nepal
  • Middle Aged
  • Male
  • Hydrocortisone
  • Humans
  • Gene-Environment Interaction