Skip to main content

Retinal microvascular abnormalities and risk of renal failure in Asian populations.

Publication ,  Journal Article
Yip, W; Sabanayagam, C; Teo, BW; Tay, WT; Ikram, MK; Tai, ES; Chow, KY; Wong, TY; Cheung, CY
Published in: PLoS One
2015

BACKGROUND: Retinal microvascular signs may provide insights into the structure and function of small vessels that are associated with renal disease. We examined the relationship of retinal microvascular signs with both prevalent and incident end-stage renal disease (ESRD) in a multi-ethnic Asian population. METHODS: A total of 5763 subjects (aged ≥ 40 years) from two prospective population-based studies (the Singapore Malay Eye Study and the Singapore Prospective Study) were included for the current analysis. Retinopathy was graded using the modified Airlie House classification system. Retinal vascular parameters were measured using computer-assisted programs to quantify the retinal vessel widths (arteriolar and venular caliber) and retinal vascular network (fractal dimension). Data on ESRD was obtained by record linkage with the ESRD cases registered by National Registry of Diseases Office, Singapore. Multi-variable adjusted regression analyses were performed to assess the associations of baseline retinal vascular parameters and prevalent and incident ESRD. RESULTS: At baseline, 21(0.36%) persons had prevalent ESRD. During a median follow-up of 4.3 years, 33 (0.57%) subjects developed ESRD. In our analyses, retinopathy was associated with prevalent ESRD (multi-variable adjusted odds ratio [OR], 3.21, 95% confidence interval [CI]: 1.28-8.05) and incident ESRD (multi-variable adjusted hazard ratio [HR], 2.51, 95%CI: 1.14-5.54). This association was largely seen in person with diabetes (HR, 2.60, 95%CI: 1.01-6.66) and not present in persons without diabetes (HR, 1.65, 95%CI: 0.14-18.98). Retinal arteriolar caliber, retinal venular caliber and retinal vascular fractal dimension were not associated with ESRD. CONCLUSION: Retinopathy signs in persons with diabetes are related to an increased risk of ESRD; however, other microvascular changes in the retina are not associated with ESRD.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

2

Start / End Page

e0118076

Location

United States

Related Subject Headings

  • Singapore
  • Retinal Vessels
  • Retinal Diseases
  • Renal Insufficiency
  • Registries
  • Prevalence
  • Population Surveillance
  • Patient Outcome Assessment
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yip, W., Sabanayagam, C., Teo, B. W., Tay, W. T., Ikram, M. K., Tai, E. S., … Cheung, C. Y. (2015). Retinal microvascular abnormalities and risk of renal failure in Asian populations. PLoS One, 10(2), e0118076. https://doi.org/10.1371/journal.pone.0118076
Yip, WanFen, Charumathi Sabanayagam, Boon Wee Teo, Wan Ting Tay, M Kamran Ikram, E Shyong Tai, Khuan Yew Chow, Tien Y. Wong, and Carol Y. Cheung. “Retinal microvascular abnormalities and risk of renal failure in Asian populations.PLoS One 10, no. 2 (2015): e0118076. https://doi.org/10.1371/journal.pone.0118076.
Yip W, Sabanayagam C, Teo BW, Tay WT, Ikram MK, Tai ES, et al. Retinal microvascular abnormalities and risk of renal failure in Asian populations. PLoS One. 2015;10(2):e0118076.
Yip, WanFen, et al. “Retinal microvascular abnormalities and risk of renal failure in Asian populations.PLoS One, vol. 10, no. 2, 2015, p. e0118076. Pubmed, doi:10.1371/journal.pone.0118076.
Yip W, Sabanayagam C, Teo BW, Tay WT, Ikram MK, Tai ES, Chow KY, Wong TY, Cheung CY. Retinal microvascular abnormalities and risk of renal failure in Asian populations. PLoS One. 2015;10(2):e0118076.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2015

Volume

10

Issue

2

Start / End Page

e0118076

Location

United States

Related Subject Headings

  • Singapore
  • Retinal Vessels
  • Retinal Diseases
  • Renal Insufficiency
  • Registries
  • Prevalence
  • Population Surveillance
  • Patient Outcome Assessment
  • Middle Aged
  • Male