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Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls.

Publication ,  Journal Article
Meier, MH; Gillespie, NA; Hansell, NK; Hewitt, AW; Hickie, IB; Lu, Y; McGrath, J; MacGregor, S; Medland, SE; Sun, C; Wong, TY; Wright, MJ ...
Published in: Schizophr Res
May 2015

Mounting evidence suggests that individuals with schizophrenia have an underlying vulnerability to cardiovascular disease, and a recent study suggested that this vulnerability might be reflected in the retinal microvasculature. The purpose of this study was to test the hypothesis that the retinal microvessels reflect familial vulnerability to psychotic symptoms. Participants were 531 adolescent and young adult twins who took part in the Brisbane Longitudinal Twin Study and the Twins Eye Study in Tasmania. The twins had photographs taken of their retina when they were adolescents or young adults (M age=20.6 years), and retinal vessel diameter was assessed using computer software. The twins completed an assessment of psychosis symptoms approximately six years later. We compared retinal venular diameters of individuals with one or more symptoms of psychosis (n=45), their unaffected co-twins (n=24), and controls (n=462). Individuals with one or more symptoms of psychosis had wider venules (standardized mean=0.29) than controls (standardized mean=-0.04; p=.03), and unaffected co-twins had venular diameters that were intermediate (standardized mean=0.13) between the two groups, suggesting that wide venules may represent a proxy marker of familial vulnerability to psychosis symptoms. Consistent with previous work, there were no differences in arteriolar diameter between individuals with and without symptoms of psychosis. Findings suggest that wide retinal venules may serve as a proxy marker of familial liability to psychosis symptoms. The pathophysiological mechanisms linking psychosis and cardiovascular disease may be operative from early in life, possibly at the level of the microvasculature.

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Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

May 2015

Volume

164

Issue

1-3

Start / End Page

47 / 52

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Retinal Vessels
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Family Health
 

Citation

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ICMJE
MLA
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Meier, M. H., Gillespie, N. A., Hansell, N. K., Hewitt, A. W., Hickie, I. B., Lu, Y., … Mackey, D. A. (2015). Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. Schizophr Res, 164(1–3), 47–52. https://doi.org/10.1016/j.schres.2015.01.045
Meier, Madeline H., Nathan A. Gillespie, Narelle K. Hansell, Alex W. Hewitt, Ian B. Hickie, Yi Lu, John McGrath, et al. “Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls.Schizophr Res 164, no. 1–3 (May 2015): 47–52. https://doi.org/10.1016/j.schres.2015.01.045.
Meier MH, Gillespie NA, Hansell NK, Hewitt AW, Hickie IB, Lu Y, et al. Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. Schizophr Res. 2015 May;164(1–3):47–52.
Meier, Madeline H., et al. “Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls.Schizophr Res, vol. 164, no. 1–3, May 2015, pp. 47–52. Pubmed, doi:10.1016/j.schres.2015.01.045.
Meier MH, Gillespie NA, Hansell NK, Hewitt AW, Hickie IB, Lu Y, McGrath J, MacGregor S, Medland SE, Sun C, Wong TY, Wright MJ, Zhu G, Martin NG, Mackey DA. Retinal microvessels reflect familial vulnerability to psychotic symptoms: A comparison of twins discordant for psychotic symptoms and controls. Schizophr Res. 2015 May;164(1–3):47–52.
Journal cover image

Published In

Schizophr Res

DOI

EISSN

1573-2509

Publication Date

May 2015

Volume

164

Issue

1-3

Start / End Page

47 / 52

Location

Netherlands

Related Subject Headings

  • Young Adult
  • Retinal Vessels
  • Psychotic Disorders
  • Psychiatry
  • Psychiatric Status Rating Scales
  • Male
  • Longitudinal Studies
  • Humans
  • Female
  • Family Health