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The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis.

Publication ,  Journal Article
Mannava, S; Plate, JF; Tuohy, CJ; Seyler, TM; Whitlock, PW; Curl, WW; Smith, TL; Saul, KR
Published in: Knee Surg Sports Traumatol Arthrosc
July 2013

PURPOSE: The purpose of this article is to review basic science studies using various animal models for rotator cuff research and to describe structural, biomechanical, and functional changes to muscle following rotator cuff tears. The use of computational simulations to translate the findings from animal models to human scale is further detailed. METHODS: A comprehensive review was performed of the basic science literature describing the use of animal models and simulation analysis to examine muscle function following rotator cuff injury and repair in the ageing population. RESULTS: The findings from various studies of rotator cuff pathology emphasize the importance of preventing permanent muscular changes with detrimental results. In vivo muscle function, electromyography, and passive muscle-tendon unit properties were studied before and after supraspinatus tenotomy in a rodent rotator cuff injury model (acute vs chronic). Then, a series of simulation experiments were conducted using a validated computational human musculoskeletal shoulder model to assess both passive and active tension of rotator cuff repairs based on surgical positioning. CONCLUSION: Outcomes of rotator cuff repair may be improved by earlier surgical intervention, with lower surgical repair tensions and fewer electromyographic neuromuscular changes. An integrated approach of animal experiments, computer simulation analyses, and clinical studies may allow us to gain a fundamental understanding of the underlying pathology and interpret the results for clinical translation.

Duke Scholars

Published In

Knee Surg Sports Traumatol Arthrosc

DOI

EISSN

1433-7347

Publication Date

July 2013

Volume

21

Issue

7

Start / End Page

1610 / 1619

Location

Germany

Related Subject Headings

  • Tendon Injuries
  • Rotator Cuff Injuries
  • Rotator Cuff
  • Orthopedics
  • Models, Animal
  • Humans
  • Computer Simulation
  • Biomechanical Phenomena
  • Animals
  • 4207 Sports science and exercise
 

Citation

APA
Chicago
ICMJE
MLA
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Mannava, S., Plate, J. F., Tuohy, C. J., Seyler, T. M., Whitlock, P. W., Curl, W. W., … Saul, K. R. (2013). The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis. Knee Surg Sports Traumatol Arthrosc, 21(7), 1610–1619. https://doi.org/10.1007/s00167-012-2145-9
Mannava, Sandeep, Johannes F. Plate, Christopher J. Tuohy, Thorsten M. Seyler, Patrick W. Whitlock, Walton W. Curl, Thomas L. Smith, and Katherine R. Saul. “The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis.Knee Surg Sports Traumatol Arthrosc 21, no. 7 (July 2013): 1610–19. https://doi.org/10.1007/s00167-012-2145-9.
Mannava S, Plate JF, Tuohy CJ, Seyler TM, Whitlock PW, Curl WW, et al. The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis. Knee Surg Sports Traumatol Arthrosc. 2013 Jul;21(7):1610–9.
Mannava, Sandeep, et al. “The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis.Knee Surg Sports Traumatol Arthrosc, vol. 21, no. 7, July 2013, pp. 1610–19. Pubmed, doi:10.1007/s00167-012-2145-9.
Mannava S, Plate JF, Tuohy CJ, Seyler TM, Whitlock PW, Curl WW, Smith TL, Saul KR. The science of rotator cuff tears: translating animal models to clinical recommendations using simulation analysis. Knee Surg Sports Traumatol Arthrosc. 2013 Jul;21(7):1610–1619.
Journal cover image

Published In

Knee Surg Sports Traumatol Arthrosc

DOI

EISSN

1433-7347

Publication Date

July 2013

Volume

21

Issue

7

Start / End Page

1610 / 1619

Location

Germany

Related Subject Headings

  • Tendon Injuries
  • Rotator Cuff Injuries
  • Rotator Cuff
  • Orthopedics
  • Models, Animal
  • Humans
  • Computer Simulation
  • Biomechanical Phenomena
  • Animals
  • 4207 Sports science and exercise