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Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants.

Publication ,  Journal Article
Quartermain, MD; Pasquali, SK; Hill, KD; Goldberg, DJ; Huhta, JC; Jacobs, JP; Jacobs, ML; Kim, S; Ungerleider, RM
Published in: Pediatrics
August 2015

BACKGROUND AND OBJECTIVE: Prenatal diagnosis allows improved perioperative outcomes for fetuses with certain forms of congenital heart disease (CHD). Variability in prenatal diagnosis has been demonstrated in other countries, leading to efforts to improve fetal imaging protocols and access to care, but has not been examined across the United States. The objective was to evaluate national variation in prenatal detection across geographic region and defect type in neonates and infants with CHD undergoing heart surgery. METHODS: Cardiovascular operations performed in patients ≤6 months of age in the United States and included in the Society of Thoracic Surgeons Congenital Heart Surgery Database (2006-2012) were eligible for inclusion. Centers with >15% missing prenatal diagnosis data were excluded from the study. Prenatal diagnosis rates were compared across geographic location of residence and defect type using the χ(2) test. RESULTS: Overall, the study included 31,374 patients from 91 Society of Thoracic Surgeons Congenital Heart Surgery Database participating centers across the United States. Prenatal detection occurred in 34% and increased every year, from 26% (2006) to 42% (2012). There was significant geographic variation in rates of prenatal diagnosis across states (range 11.8%-53.4%, P < .0001). Significant variability by defect type was also observed, with higher rates for lesions identifiable on 4-chamber view than for those requiring outflow tract visualization (57% vs 32%, P < .0001). CONCLUSIONS: Rates of prenatal CHD detection in the United States remain low for patients undergoing surgical intervention, with significant variability between states and across defect type. Additional studies are needed to identify reasons for this variation and the potential impact on patient outcomes.

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Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

August 2015

Volume

136

Issue

2

Start / End Page

e378 / e385

Location

United States

Related Subject Headings

  • United States
  • Ultrasonography, Prenatal
  • Pregnancy
  • Pediatrics
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Heart Defects, Congenital
  • Female
 

Citation

APA
Chicago
ICMJE
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Quartermain, M. D., Pasquali, S. K., Hill, K. D., Goldberg, D. J., Huhta, J. C., Jacobs, J. P., … Ungerleider, R. M. (2015). Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants. Pediatrics, 136(2), e378–e385. https://doi.org/10.1542/peds.2014-3783
Quartermain, Michael D., Sara K. Pasquali, Kevin D. Hill, David J. Goldberg, James C. Huhta, Jeffrey P. Jacobs, Marshall L. Jacobs, Sunghee Kim, and Ross M. Ungerleider. “Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants.Pediatrics 136, no. 2 (August 2015): e378–85. https://doi.org/10.1542/peds.2014-3783.
Quartermain MD, Pasquali SK, Hill KD, Goldberg DJ, Huhta JC, Jacobs JP, et al. Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants. Pediatrics. 2015 Aug;136(2):e378–85.
Quartermain, Michael D., et al. “Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants.Pediatrics, vol. 136, no. 2, Aug. 2015, pp. e378–85. Pubmed, doi:10.1542/peds.2014-3783.
Quartermain MD, Pasquali SK, Hill KD, Goldberg DJ, Huhta JC, Jacobs JP, Jacobs ML, Kim S, Ungerleider RM. Variation in Prenatal Diagnosis of Congenital Heart Disease in Infants. Pediatrics. 2015 Aug;136(2):e378–e385.

Published In

Pediatrics

DOI

EISSN

1098-4275

Publication Date

August 2015

Volume

136

Issue

2

Start / End Page

e378 / e385

Location

United States

Related Subject Headings

  • United States
  • Ultrasonography, Prenatal
  • Pregnancy
  • Pediatrics
  • Male
  • Infant, Newborn
  • Infant
  • Humans
  • Heart Defects, Congenital
  • Female