Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study.

Publication ,  Journal Article
Chua, J; Koh, JY; Tan, AG; Zhao, W; Lamoureux, E; Mitchell, P; Wang, JJ; Wong, TY; Cheng, C-Y
Published in: Ophthalmology
November 2015

PURPOSE: To determine the prevalence of age-related cataract and its ancestral and socioeconomic risk factors in a multi-ethnic Asian population. DESIGN: Population-based, cross-sectional study. PARTICIPANTS: A total of 10 033 adults (3353 Chinese, 3280 Malays, and 3400 Indians) aged >40 years in the Singapore Epidemiology of Eye Diseases Study. METHODS: Study participants were invited for a structured interview and received a standardized comprehensive eye examination. Digital lens photographs were taken from eyes of each participant and graded for nuclear, cortical, and posterior subcapsular (PSC) cataract, following the Wisconsin Cataract Grading System. Prevalence data were compared with the Blue Mountains Eye Study (BMES) in Australia. Information on medical and lifestyle factors was collected using questionnaires and blood samples. To increase the precision of racial definition, genetic ancestry was derived from genome-wide single nucleotide polymorphism markers using principal component analysis. Regression models were used to investigate the association of cataract with socioeconomic factors (education and income) and genetic ancestry. MAIN OUTCOME MEASURES: Age-related cataract. RESULTS: A total of 8750 participants (94.0%) had gradable lens photographs. The age-standardized prevalence of cataract surgery in Chinese (16.0%), Malays (10.6%), and Indians (20.2%) was higher than in white subjects (4.1%). We found the age-standardized cataract prevalence in Chinese (30.4%), Malays (37.8%), and Indians (33.1%) was higher than in whites (18.5%). Cataract was 1.5 to 2 times more common in Asians and began 10 years earlier than in white subjects. Malays had significantly higher age-standardized prevalence of nuclear, cortical, and PSC cataract than Chinese (P<0.001). The severity of nuclear, cortical, and PSC cataract was significantly correlated with genetic ancestry in our South East Asian population. Less education and lower income were associated with cataract for Chinese and Indians but not Malays. The presence of visual impairment associated with cataract was higher in people aged ≥60 years and Malays. CONCLUSIONS: We showed that people of different Asian ethnicities had a higher prevalence and earlier age of onset of cataract than Europeans. People of Malay ancestry have a greater severity for all cataract subtypes than people of Chinese ancestry. Education and income were associated with cataract for certain Asian subgroups.

Duke Scholars

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

November 2015

Volume

122

Issue

11

Start / End Page

2169 / 2178

Location

United States

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Social Class
  • Singapore
  • Risk Factors
  • Prevalence
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Income
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Chua, J., Koh, J. Y., Tan, A. G., Zhao, W., Lamoureux, E., Mitchell, P., … Cheng, C.-Y. (2015). Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study. Ophthalmology, 122(11), 2169–2178. https://doi.org/10.1016/j.ophtha.2015.06.052
Chua, Jacqueline, Jia Yu Koh, Ava Grace Tan, Wanting Zhao, Ecosse Lamoureux, Paul Mitchell, Jie Jin Wang, Tien Yin Wong, and Ching-Yu Cheng. “Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study.Ophthalmology 122, no. 11 (November 2015): 2169–78. https://doi.org/10.1016/j.ophtha.2015.06.052.
Chua J, Koh JY, Tan AG, Zhao W, Lamoureux E, Mitchell P, et al. Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study. Ophthalmology. 2015 Nov;122(11):2169–78.
Chua, Jacqueline, et al. “Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study.Ophthalmology, vol. 122, no. 11, Nov. 2015, pp. 2169–78. Pubmed, doi:10.1016/j.ophtha.2015.06.052.
Chua J, Koh JY, Tan AG, Zhao W, Lamoureux E, Mitchell P, Wang JJ, Wong TY, Cheng C-Y. Ancestry, Socioeconomic Status, and Age-Related Cataract in Asians: The Singapore Epidemiology of Eye Diseases Study. Ophthalmology. 2015 Nov;122(11):2169–2178.
Journal cover image

Published In

Ophthalmology

DOI

EISSN

1549-4713

Publication Date

November 2015

Volume

122

Issue

11

Start / End Page

2169 / 2178

Location

United States

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Social Class
  • Singapore
  • Risk Factors
  • Prevalence
  • Ophthalmology & Optometry
  • Middle Aged
  • Male
  • Income