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Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.

Publication ,  Journal Article
Wang, M-Y; Li, Q-X; He, J; Qiu, L-X; Wang, Y-N; Li, J; Sun, M-H; Wang, X-F; Yang, Y-J; Wang, J-C; Jin, L; Wei, Q-Y
Published in: Pharmacogenet Genomics
November 2015

BACKGROUND AND AIM: Genetic variants in the mammalian target of rapamycin (mTOR) gene have become an interesting topic for the study of genetic susceptibility to cancer, but their associations with the risk of gastric cancer have not been fully investigated. MATERIALS AND METHODS: In a hospital-based case-control study of 1002 gastric cancer patients and 1003 cancer-free controls, we genotyped four potentially functional single nucleotide polymorphisms (SNPs) (rs1034528G>C, rs17036508T>C, rs3806317A>G, and rs2295080T>G) of mTOR and assessed their associations with the risk of gastric cancer using univariate and multivariate logistic regression analyses. We also used the multifactorial dimension reduction analysis to explore possible interactions and the false-positive report probabilities to assess significant findings. RESULTS: We found that rs1034528 CG/CC and rs3806317 GA/GG variant genotypes were associated with an increased risk of gastric cancer under a dominant model (adjusted odds ratio=1.27 and 1.22, respectively). In the combined analysis of all four SNPs under investigation, patients with 3-4 risk genotypes of mTOR had a significantly increased risk of gastric cancer (adjusted odds ratio=1.46, 95% confidence interval=1.19-1.79) compared with those with 0-2 risk genotypes. Stratified analysis indicated that this risk was more pronounced in subgroups of men, never-smokers, never-drinkers, and clinical stages III+IV. The multifactorial dimension reduction analysis suggested some evidence of interactions between the combined genotypes and other risk factors for gastric cancer. CONCLUSION: These findings suggest that potentially functional SNPs of mTOR may individually or collectively contribute to the risk of gastric cancer. Larger studies with diverse ethnic populations are warranted to validate our findings.

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Published In

Pharmacogenet Genomics

DOI

EISSN

1744-6880

Publication Date

November 2015

Volume

25

Issue

11

Start / End Page

521 / 530

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • Stomach Neoplasms
  • Risk Factors
  • RNA, Messenger
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Models, Genetic
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
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Wang, M.-Y., Li, Q.-X., He, J., Qiu, L.-X., Wang, Y.-N., Li, J., … Wei, Q.-Y. (2015). Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population. Pharmacogenet Genomics, 25(11), 521–530. https://doi.org/10.1097/FPC.0000000000000163
Wang, Meng-Yun, Qiao-Xin Li, Jing He, Li-Xin Qiu, Ya-Nong Wang, Jin Li, Meng-Hong Sun, et al. “Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.Pharmacogenet Genomics 25, no. 11 (November 2015): 521–30. https://doi.org/10.1097/FPC.0000000000000163.
Wang M-Y, Li Q-X, He J, Qiu L-X, Wang Y-N, Li J, et al. Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population. Pharmacogenet Genomics. 2015 Nov;25(11):521–30.
Wang, Meng-Yun, et al. “Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population.Pharmacogenet Genomics, vol. 25, no. 11, Nov. 2015, pp. 521–30. Pubmed, doi:10.1097/FPC.0000000000000163.
Wang M-Y, Li Q-X, He J, Qiu L-X, Wang Y-N, Li J, Sun M-H, Wang X-F, Yang Y-J, Wang J-C, Jin L, Wei Q-Y. Genetic variations in the mTOR gene contribute toward gastric adenocarcinoma susceptibility in an Eastern Chinese population. Pharmacogenet Genomics. 2015 Nov;25(11):521–530.

Published In

Pharmacogenet Genomics

DOI

EISSN

1744-6880

Publication Date

November 2015

Volume

25

Issue

11

Start / End Page

521 / 530

Location

United States

Related Subject Headings

  • TOR Serine-Threonine Kinases
  • Stomach Neoplasms
  • Risk Factors
  • RNA, Messenger
  • Polymorphism, Single Nucleotide
  • Pharmacology & Pharmacy
  • Models, Genetic
  • Middle Aged
  • Male
  • Humans