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Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.

Publication ,  Journal Article
Salvatore, JE; Meyers, JL; Yan, J; Aliev, F; Lansford, JE; Pettit, GS; Bates, JE; Dodge, KA; Rose, RJ; Pulkkinen, L; Kaprio, J; Dick, DM
Published in: Journal of abnormal psychology
August 2015

We examine whether parental externalizing behavior has an indirect effect on adolescent externalizing behavior via elevations in life events, and whether this indirect effect is further qualified by an interaction between life events and adolescents' GABRA2 genotype (rs279871). We use data from 2 samples: the Child Development Project (CDP; n = 324) and FinnTwin12 (n = 802). In CDP, repeated measures of life events, mother-reported adolescent externalizing, and teacher-reported adolescent externalizing were used. In FinnTwin12, life events and externalizing were assessed at age 14. Parental externalizing was indexed by measures of antisocial behavior and alcohol problems or alcohol dependence symptoms in both samples. In CDP, parental externalizing was associated with more life events, and the association between life events and subsequent adolescent externalizing varied as a function of GABRA2 genotype (p ≤ .05). The association between life events and subsequent adolescent externalizing was stronger for adolescents with 0 copies of the G minor allele compared to those with 1 or 2 copies of the minor allele. Parallel moderation trends were observed in FinnTwin12 (p ≤ .11). The discussion focuses on how the strength of intergenerational pathways for externalizing psychopathology may differ as a function of adolescent-level individual differences.

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Published In

Journal of abnormal psychology

DOI

EISSN

1939-1846

ISSN

0021-843X

Publication Date

August 2015

Volume

124

Issue

3

Start / End Page

709 / 728

Related Subject Headings

  • Twins
  • Receptors, GABA-A
  • Polymorphism, Single Nucleotide
  • Parents
  • Parent-Child Relations
  • Male
  • Life Change Events
  • Humans
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

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Salvatore, J. E., Meyers, J. L., Yan, J., Aliev, F., Lansford, J. E., Pettit, G. S., … Dick, D. M. (2015). Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. Journal of Abnormal Psychology, 124(3), 709–728. https://doi.org/10.1037/abn0000066
Salvatore, Jessica E., Jacquelyn L. Meyers, Jia Yan, Fazil Aliev, Jennifer E. Lansford, Gregory S. Pettit, John E. Bates, et al. “Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.Journal of Abnormal Psychology 124, no. 3 (August 2015): 709–28. https://doi.org/10.1037/abn0000066.
Salvatore JE, Meyers JL, Yan J, Aliev F, Lansford JE, Pettit GS, et al. Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. Journal of abnormal psychology. 2015 Aug;124(3):709–28.
Salvatore, Jessica E., et al. “Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2.Journal of Abnormal Psychology, vol. 124, no. 3, Aug. 2015, pp. 709–28. Epmc, doi:10.1037/abn0000066.
Salvatore JE, Meyers JL, Yan J, Aliev F, Lansford JE, Pettit GS, Bates JE, Dodge KA, Rose RJ, Pulkkinen L, Kaprio J, Dick DM. Intergenerational continuity in parents' and adolescents' externalizing problems: The role of life events and their interaction with GABRA2. Journal of abnormal psychology. 2015 Aug;124(3):709–728.

Published In

Journal of abnormal psychology

DOI

EISSN

1939-1846

ISSN

0021-843X

Publication Date

August 2015

Volume

124

Issue

3

Start / End Page

709 / 728

Related Subject Headings

  • Twins
  • Receptors, GABA-A
  • Polymorphism, Single Nucleotide
  • Parents
  • Parent-Child Relations
  • Male
  • Life Change Events
  • Humans
  • Genotype
  • Genetic Predisposition to Disease