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Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women.

Publication ,  Journal Article
Shi, T-Y; Zhu, M-L; He, J; Wang, M-Y; Li, Q-X; Zhou, X-Y; Sun, M-H; Shao, Z-M; Yu, K-D; Cheng, X; Wu, X; Wei, Q
Published in: Hum Genet
March 2013

Interleukin 6 (IL6) encodes a cytokine protein, which functions in inflammation, maintains immune homeostasis and plays important roles in cervical carcinogenesis. Single nucleotide polymorphisms (SNPs) in IL6 that cause variations in host immune response may contribute to cervical cancer risk. In this two-stage case-control study with a total of 1,584 cervical cancer cases and 1,768 cancer-free female controls, we investigated associations between two IL6 SNPs and cervical cancer risk in Eastern Chinese women. In both Study 1 and Study 2, we found a significant association of the IL6-rs2069837 SNP with an increased risk of cervical cancer as well as in their combined data (OR 1.27 and 1.19, 95% CI 1.08-1.49 and 1.04-1.36, P = 0.004 and 0.014 for dominant and additive genetic models, respectively). Furthermore, rs2069837 variant AG/GG carriers showed significantly higher levels of IL6 protein than did rs2069837 AA carriers in the target tissues. Using multifactor dimensionality reduction (MDR) and classification and regression tree (CART) analyses, we observed some evidence of interactions of the IL6 rs2069837 SNP with age at primiparity and menopausal status in cervical cancer risk. We concluded that the IL6-rs2069837 SNP may be a marker for susceptibility to cervical cancer in Eastern Chinese women by a possible mechanism of altering the IL6 protein expression. Although lacked information on human papillomavirus (HPV) infection, our study also suggested possible interactions between IL6 genotypes and age at primiparity or menopausal status in cervical carcinogenesis. However, larger, independent studies with detailed HPV infection data are warranted to validate our findings.

Duke Scholars

Published In

Hum Genet

DOI

EISSN

1432-1203

Publication Date

March 2013

Volume

132

Issue

3

Start / End Page

301 / 312

Location

Germany

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Parity
  • Neoplasm Staging
  • Middle Aged
  • Menopause
  • Logistic Models
  • Interleukin-6
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Shi, T.-Y., Zhu, M.-L., He, J., Wang, M.-Y., Li, Q.-X., Zhou, X.-Y., … Wei, Q. (2013). Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women. Hum Genet, 132(3), 301–312. https://doi.org/10.1007/s00439-012-1245-4
Shi, Ting-Yan, Mei-Ling Zhu, Jing He, Meng-Yun Wang, Qiao-Xin Li, Xiao-Yan Zhou, Meng-Hong Sun, et al. “Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women.Hum Genet 132, no. 3 (March 2013): 301–12. https://doi.org/10.1007/s00439-012-1245-4.
Shi T-Y, Zhu M-L, He J, Wang M-Y, Li Q-X, Zhou X-Y, et al. Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women. Hum Genet. 2013 Mar;132(3):301–12.
Shi, Ting-Yan, et al. “Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women.Hum Genet, vol. 132, no. 3, Mar. 2013, pp. 301–12. Pubmed, doi:10.1007/s00439-012-1245-4.
Shi T-Y, Zhu M-L, He J, Wang M-Y, Li Q-X, Zhou X-Y, Sun M-H, Shao Z-M, Yu K-D, Cheng X, Wu X, Wei Q. Polymorphisms of the Interleukin 6 gene contribute to cervical cancer susceptibility in Eastern Chinese women. Hum Genet. 2013 Mar;132(3):301–312.
Journal cover image

Published In

Hum Genet

DOI

EISSN

1432-1203

Publication Date

March 2013

Volume

132

Issue

3

Start / End Page

301 / 312

Location

Germany

Related Subject Headings

  • Uterine Cervical Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Parity
  • Neoplasm Staging
  • Middle Aged
  • Menopause
  • Logistic Models
  • Interleukin-6
  • Humans