Scholars@Duke

A variant in FTO shows association with melanoma risk not due to BMI.

Publication ,  Journal Article
Iles, MM; Law, MH; Stacey, SN; Han, J; Fang, S; Pfeiffer, R; Harland, M; Macgregor, S; Taylor, JC; Aben, KK; Akslen, LA; Avril, M-F; Azizi, E ...
Published in: Nat Genet
April 2013
Published version (DOI) Link to item

We report the results of an association study of melanoma that is based on the genome-wide imputation of the genotypes of 1,353 cases and 3,566 controls of European origin conducted by the GenoMEL consortium. This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from Europe, the USA and Australia (combined P = 3.6 × 10(-12), per-allele odds ratio for allele A = 1.16). In addition to identifying a new melanoma-susceptibility locus, this is to our knowledge the first study to identify and replicate an association with SNPs in FTO not related to body mass index (BMI). These SNPs are not in intron 1 (the BMI-related region) and exhibit no association with BMI. This suggests FTO's function may be broader than the existing paradigm that FTO variants influence multiple traits only through their associations with BMI and obesity.

Duke Scholars

Qingyi Wei
Author Qingyi Wei Population Health Sciences
Altmetric Attention Stats
Dimensions Citation Stats

Published In

Nat Genet

DOI

10.1038/ng.2571

EISSN

1546-1718

Publication Date

April 2013

Volume

45

Issue

4

Start / End Page

428 / 432e1

Location

United States

Related Subject Headings

  • Risk Factors
  • Proteins
  • Polymorphism, Single Nucleotide
  • Obesity
  • Meta-Analysis as Topic
  • Melanoma
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Iles, M. M., Law, M. H., Stacey, S. N., Han, J., Fang, S., Pfeiffer, R., … Q-MEGA and AMFS Investigators. (2013). A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet, 45(4), 428-432e1. https://doi.org/10.1038/ng.2571
Iles, Mark M., Matthew H. Law, Simon N. Stacey, Jiali Han, Shenying Fang, Ruth Pfeiffer, Mark Harland, et al. “A variant in FTO shows association with melanoma risk not due to BMI.” Nat Genet 45, no. 4 (April 2013): 428-432e1. https://doi.org/10.1038/ng.2571.
Iles MM, Law MH, Stacey SN, Han J, Fang S, Pfeiffer R, et al. A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet. 2013 Apr;45(4):428-432e1.
Iles, Mark M., et al. “A variant in FTO shows association with melanoma risk not due to BMI.” Nat Genet, vol. 45, no. 4, Apr. 2013, pp. 428-432e1. Pubmed, doi:10.1038/ng.2571.
Iles MM, Law MH, Stacey SN, Han J, Fang S, Pfeiffer R, Harland M, Macgregor S, Taylor JC, Aben KK, Akslen LA, Avril M-F, Azizi E, Bakker B, Benediktsdottir KR, Bergman W, Scarrà GB, Brown KM, Calista D, Chaudru V, Fargnoli MC, Cust AE, Demenais F, de Waal AC, Dębniak T, Elder DE, Friedman E, Galan P, Ghiorzo P, Gillanders EM, Goldstein AM, Gruis NA, Hansson J, Helsing P, Hočevar M, Höiom V, Hopper JL, Ingvar C, Janssen M, Jenkins MA, Kanetsky PA, Kiemeney LA, Lang J, Lathrop GM, Leachman S, Lee JE, Lubiński J, Mackie RM, Mann GJ, Martin NG, Mayordomo JI, Molven A, Mulder S, Nagore E, Novaković S, Okamoto I, Olafsson JH, Olsson H, Pehamberger H, Peris K, Grasa MP, Planelles D, Puig S, Puig-Butille JA, Randerson-Moor J, Requena C, Rivoltini L, Rodolfo M, Santinami M, Sigurgeirsson B, Snowden H, Song F, Sulem P, Thorisdottir K, Tuominen R, Van Belle P, van der Stoep N, van Rossum MM, Wei Q, Wendt J, Zelenika D, Zhang M, Landi MT, Thorleifsson G, Bishop DT, Amos CI, Hayward NK, Stefansson K, Bishop JAN, Barrett JH, GenoMEL Consortium, Q-MEGA and AMFS Investigators. A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet. 2013 Apr;45(4):428-432e1.

Published In

Nat Genet

DOI

10.1038/ng.2571

EISSN

1546-1718

Publication Date

April 2013

Volume

45

Issue

4

Start / End Page

428 / 432e1

Location

United States

Related Subject Headings

  • Risk Factors
  • Proteins
  • Polymorphism, Single Nucleotide
  • Obesity
  • Meta-Analysis as Topic
  • Melanoma
  • Humans
  • Genotype
  • Genome-Wide Association Study
  • Genetic Predisposition to Disease