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Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx.

Publication ,  Journal Article
Song, X; Sturgis, EM; Jin, L; Wang, Z; Wei, Q; Li, G
Published in: Int J Cancer
August 1, 2013

Genetically determined capacity for NER may modulate both cancer risk and prognosis. Thus, we evaluated associations of seven selected variants in the NER core genes with recurrence risk in 658 squamous cell carcinoma of the oropharynx (SCCOP) patients treated principally by radiation. The seven polymorphisms in the core NER genes (XPC-rs2228000, XPC-rs2228001, XPD-rs1799793, XPD-rs13181, XPG-rs17655, ERCC1-rs3212986 and XPA-rs1800975) were genotyped using PCR-RFLP method and log-rank test and multivariable Cox models were used to evaluate the associations in both dominant and recessive genetic models. In a dominant model, we found that polymorphisms of XPC-rs2228000, XPD-rs1799793 and XPG-rs17655 were significantly associated with disease-free survival (log-rank, p = 0.014; p = 0.00008; p = 0.0007, respectively), and these polymorphisms were significantly associated with recurrence risk of SCCOP (hazard ratio (HR) = 1.6, 95% confidence interval (CI) 1.1-2.3 for XPC-rs2228000; HR = 0.4, 95% 0.3-0.6 for XPD-rs1799793 and HR = 0.5, 95% CI 0.4-0.8 for XPG-rs17655) after multivariable adjustment. Moreover, the borderline significant or significant associations were also found for these three polymorphisms in HPV16/18-positive SCCOP patients (HR = 1.6, 95% CI 1.0-4.1 for XPC-rs2228000; HR = 0.2, 95% CI 0.1-0.5 for XPD-rs1799793 and HR = 0.1, 95% CI 0.0-0.9 for XPG-rs17655). However, similarly significant associations were not found for these polymorphisms in a recessive model. These findings suggest that polymorphisms of XPC-rs2228000, XPD-rs1799793 and XPG-rs17655 in the NER core genes may contribute to recurrence risk of SCCOP, particularly HPV-positive SCCOP, in a dominant but not in a recessive model. However, validation of these results is warranted.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2013

Volume

133

Issue

3

Start / End Page

695 / 704

Location

United States

Related Subject Headings

  • Xeroderma Pigmentosum Group D Protein
  • Xeroderma Pigmentosum Group A Protein
  • Transcription Factors
  • Survival Analysis
  • Risk
  • Polymorphism, Single Nucleotide
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Recurrence, Local
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Song, X., Sturgis, E. M., Jin, L., Wang, Z., Wei, Q., & Li, G. (2013). Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. Int J Cancer, 133(3), 695–704. https://doi.org/10.1002/ijc.28051
Song, Xicheng, Erich M. Sturgis, Lei Jin, Zhongqiu Wang, Qingyi Wei, and Guojun Li. “Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx.Int J Cancer 133, no. 3 (August 1, 2013): 695–704. https://doi.org/10.1002/ijc.28051.
Song X, Sturgis EM, Jin L, Wang Z, Wei Q, Li G. Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. Int J Cancer. 2013 Aug 1;133(3):695–704.
Song, Xicheng, et al. “Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx.Int J Cancer, vol. 133, no. 3, Aug. 2013, pp. 695–704. Pubmed, doi:10.1002/ijc.28051.
Song X, Sturgis EM, Jin L, Wang Z, Wei Q, Li G. Variants in nucleotide excision repair core genes and susceptibility to recurrence of squamous cell carcinoma of the oropharynx. Int J Cancer. 2013 Aug 1;133(3):695–704.

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

August 1, 2013

Volume

133

Issue

3

Start / End Page

695 / 704

Location

United States

Related Subject Headings

  • Xeroderma Pigmentosum Group D Protein
  • Xeroderma Pigmentosum Group A Protein
  • Transcription Factors
  • Survival Analysis
  • Risk
  • Polymorphism, Single Nucleotide
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Nuclear Proteins
  • Neoplasm Recurrence, Local