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Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.

Publication ,  Journal Article
Wang, M-Y; Zhu, M-L; He, J; Shi, T-Y; Li, Q-X; Wang, Y-N; Li, J; Zhou, X-Y; Sun, M-H; Wang, X-F; Yang, Y-J; Wang, J-C; Jin, L; Wei, Q-Y
Published in: PLoS One
2013

BACKGROUND: Caspase 7 (CASP7) is an important regulator and executioner in the apoptosis pathway and plays a crucial role in cancer development and progression. However, few studies have evaluated associations between functional single nucleotide polymorphisms (SNPs) in the 3' untranslational region (UTR) of CASP7 and risk of gastric cancer. METHODS: In a case-control study of 1117 patients with gastric cancer and 1146 cancer-free controls with frequency matching on age and sex, we genotyped four potentially functional SNPs (rs4353229T>C, rs10787498T>G, rs1127687G>A and rs12247479G>A) located in the microRNA binding sites of the CASP7 3' UTR by using Taqman assays and evaluated their associations with risk of gastric cancer by using logistic regression analyses as well as multifactorial dimension reduction (MDR) analysis. RESULTS: In the single-locus analysis, only the CASP7 rs4353229 TT genotype was associated with 0.83-fold decreased risk (95% confidence interval [CI] = 0.70-0.98) of gastric cancer under a recessive model, compared with the CT/CC genotypes. In the combined analysis of all four SNPs, we found that the risk of gastric cancer decreased by 19% in those carrying any of the risk genotypes (adjusted odds ratio = 0.81, 95% CI = 0.68-0.96), compared with those carrying zero risk genotypes, and this risk was more evident in subgroups of younger age (<59 years), females, non-smokers, non-drinkers and patients with non-gastric cardia adenocarcinoma. Further MDR analysis suggested some evidence of interactions between the combined genotypes and other risk factors for gastric cancer. CONCLUSIONS: Potentially functional CASP7 variants may contribute to risk of gastric cancer. Larger studies with different ethnic populations are warranted to validate our findings.

Duke Scholars

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

9

Start / End Page

e74041

Location

United States

Related Subject Headings

  • Young Adult
  • Stomach Neoplasms
  • RNA, Messenger
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
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Wang, M.-Y., Zhu, M.-L., He, J., Shi, T.-Y., Li, Q.-X., Wang, Y.-N., … Wei, Q.-Y. (2013). Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One, 8(9), e74041. https://doi.org/10.1371/journal.pone.0074041
Wang, Meng-Yun, Mei-Ling Zhu, Jing He, Ting-Yan Shi, Qiao-Xin Li, Ya-Nong Wang, Jin Li, et al. “Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.PLoS One 8, no. 9 (2013): e74041. https://doi.org/10.1371/journal.pone.0074041.
Wang, Meng-Yun, et al. “Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population.PLoS One, vol. 8, no. 9, 2013, p. e74041. Pubmed, doi:10.1371/journal.pone.0074041.
Wang M-Y, Zhu M-L, He J, Shi T-Y, Li Q-X, Wang Y-N, Li J, Zhou X-Y, Sun M-H, Wang X-F, Yang Y-J, Wang J-C, Jin L, Wei Q-Y. Potentially functional polymorphisms in the CASP7 gene contribute to gastric adenocarcinoma susceptibility in an eastern Chinese population. PLoS One. 2013;8(9):e74041.

Published In

PLoS One

DOI

EISSN

1932-6203

Publication Date

2013

Volume

8

Issue

9

Start / End Page

e74041

Location

United States

Related Subject Headings

  • Young Adult
  • Stomach Neoplasms
  • RNA, Messenger
  • Prognosis
  • Polymorphism, Single Nucleotide
  • Middle Aged
  • Male
  • Linkage Disequilibrium
  • Humans
  • Genotype