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Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.

Publication ,  Journal Article
Zhang, C; Sturgis, EM; Zheng, H; Song, X; Wei, P; Jin, L; Chao, L; Wei, Q; Li, G
Published in: Int J Cancer
April 15, 2014

The promoter variants of TNF-α, a major regulator of immune and inflammation responses, have been implicated in cancer development and prognosis. Thus, we investigated associations between four TNF-α promoter variants and risk of recurrence of squamous cell carcinoma of the oropharynx (SCCOP). We evaluated associations of four TNF-α polymorphisms with risk of recurrence in a cohort of 846 patients with SCCOP. Log-rank test and multivariable Cox models were used to evaluate associations. Compared with patients with variant genotypes of the TNF-α -308 and TNF-α -863 polymorphisms, patients with common homozygous genotypes had worse disease-free survival (log-rank p = 0.0002 and p < 0.0001, respectively) and increased risk of SCCOP recurrence (HR, 1.9, 95% CI, 1.3-2.8 and HR, 1.9, 95% CI, 1.3-2.7, respectively) after multivariable adjustment. Furthermore, among patients with HPV16-positive tumors, those with common homozygous genotypes of the TNF-α -308 and -863 polymorphisms had worse disease-free survival (log-rank p = 0.005 and p = 0.007, respectively) and higher recurrence risk than patients with variant genotypes of these polymorphisms (HR, 5.1, 95% CI, 1.4-18.4 and HR, 3.7, 95% CI, 1.5-9.1, respectively), while no such significant associations were found for TNF-α -857 or -1031 polymorphisms. Our findings suggest that TNF-α -308 and -863 polymorphisms may modulate the risk of SCCOP recurrence in patients with HPV16-positive tumors. However, larger studies are needed to validate these results.

Duke Scholars

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

April 15, 2014

Volume

134

Issue

8

Start / End Page

1907 / 1915

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Risk
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zhang, C., Sturgis, E. M., Zheng, H., Song, X., Wei, P., Jin, L., … Li, G. (2014). Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy. Int J Cancer, 134(8), 1907–1915. https://doi.org/10.1002/ijc.28512
Zhang, Caiyun, Erich M. Sturgis, Hongliang Zheng, Xicheng Song, Peng Wei, Lei Jin, Li Chao, Qingyi Wei, and Guojun Li. “Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.Int J Cancer 134, no. 8 (April 15, 2014): 1907–15. https://doi.org/10.1002/ijc.28512.
Zhang C, Sturgis EM, Zheng H, Song X, Wei P, Jin L, et al. Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy. Int J Cancer. 2014 Apr 15;134(8):1907–15.
Zhang, Caiyun, et al. “Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy.Int J Cancer, vol. 134, no. 8, Apr. 2014, pp. 1907–15. Pubmed, doi:10.1002/ijc.28512.
Zhang C, Sturgis EM, Zheng H, Song X, Wei P, Jin L, Chao L, Wei Q, Li G. Genetic variants in TNF-α promoter are predictors of recurrence in patients with squamous cell carcinoma of oropharynx after definitive radiotherapy. Int J Cancer. 2014 Apr 15;134(8):1907–1915.
Journal cover image

Published In

Int J Cancer

DOI

EISSN

1097-0215

Publication Date

April 15, 2014

Volume

134

Issue

8

Start / End Page

1907 / 1915

Location

United States

Related Subject Headings

  • Tumor Necrosis Factor-alpha
  • Risk
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Papillomavirus Infections
  • Oropharyngeal Neoplasms
  • Oncology & Carcinogenesis
  • Neoplasm Recurrence, Local
  • Middle Aged
  • Male