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Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms.

Publication ,  Journal Article
Hanson, JL; Hariri, AR; Williamson, DE
Published in: Biological psychiatry
November 2015

Emotional neglect is associated with multiple negative outcomes, particularly increased risk for depression. Motivated by increasing evidence of reward-related ventral striatum (VS) dysfunction in depression, we investigated the role of developmental changes in VS activity on the emergence of depressive symptomatology as a function of emotional neglect.We examined relationships between longitudinal neuroimaging of reward-related VS activity, assessments of mood, and measures of emotional neglect in 106 participants first scanned between ages 11 to 15 and then 2 years later.We found that greater levels of emotional neglect were associated with blunted development of reward-related VS activity between the first and second assessments (as indexed by lower residualized change scores). Additionally, we found that decreases in this reward-related VS activity were related to greater depressive symptomatology and partially mediated the association between emotional neglect and subsequent depressive symptomatology.Our results provide an important demonstration that blunted development of reward-related VS activity as a function of emotional neglect predicts the emergence of depressive symptoms in adolescents. Further, our results are consistent with emerging evidence for the importance of reward-related VS dysfunction in the etiology and pathophysiology of depression. These results are a first step toward developing the ability to predict, prevent, and treat stress-related psychopathology through the targeting of specific neural phenotypes.

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Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

November 2015

Volume

78

Issue

9

Start / End Page

598 / 605

Related Subject Headings

  • Ventral Striatum
  • Reward
  • Psychology, Adolescent
  • Psychiatry
  • Prognosis
  • Oxygen
  • Neuropsychological Tests
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies
 

Citation

APA
Chicago
ICMJE
MLA
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Hanson, J. L., Hariri, A. R., & Williamson, D. E. (2015). Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms. Biological Psychiatry, 78(9), 598–605. https://doi.org/10.1016/j.biopsych.2015.05.010
Hanson, Jamie L., Ahmad R. Hariri, and Douglas E. Williamson. “Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms.Biological Psychiatry 78, no. 9 (November 2015): 598–605. https://doi.org/10.1016/j.biopsych.2015.05.010.
Hanson JL, Hariri AR, Williamson DE. Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms. Biological psychiatry. 2015 Nov;78(9):598–605.
Hanson, Jamie L., et al. “Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms.Biological Psychiatry, vol. 78, no. 9, Nov. 2015, pp. 598–605. Epmc, doi:10.1016/j.biopsych.2015.05.010.
Hanson JL, Hariri AR, Williamson DE. Blunted Ventral Striatum Development in Adolescence Reflects Emotional Neglect and Predicts Depressive Symptoms. Biological psychiatry. 2015 Nov;78(9):598–605.
Journal cover image

Published In

Biological psychiatry

DOI

EISSN

1873-2402

ISSN

0006-3223

Publication Date

November 2015

Volume

78

Issue

9

Start / End Page

598 / 605

Related Subject Headings

  • Ventral Striatum
  • Reward
  • Psychology, Adolescent
  • Psychiatry
  • Prognosis
  • Oxygen
  • Neuropsychological Tests
  • Male
  • Magnetic Resonance Imaging
  • Longitudinal Studies