Gene rearrangements testing
Publication
, Journal Article
Sebastian, S; Du, J; Naeem, R
Published in: Modern Clinical Molecular Techniques
2013
© 2012 Springer Science+Business Media, LLC. All rights reserved.The B- and T-cell gene rearrangement test is one of the hallmarks of the molecular pathology diagnostic laboratories. Historically done with Southern blot and now adopted by many laboratories using PCR, the test is used as an aid in pathology diagnosis to distinguish between benign lymphoproliferative disorders, usually polyclonal, and clonally derived cell populations seen in malignant cell population. Clonally amplified gene rearrangements can be used for diagnosis and as tumor-specific markers to monitor recurrence.
Duke Scholars
Published In
Modern Clinical Molecular Techniques
DOI
Publication Date
2013
Start / End Page
245 / 259
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Sebastian, S., Du, J., & Naeem, R. (2013). Gene rearrangements testing. Modern Clinical Molecular Techniques, 245–259. https://doi.org/10.1007/978-1-4614-2170-2-17
Sebastian, S., J. Du, and R. Naeem. “Gene rearrangements testing.” Modern Clinical Molecular Techniques, 2013, 245–59. https://doi.org/10.1007/978-1-4614-2170-2-17.
Sebastian S, Du J, Naeem R. Gene rearrangements testing. Modern Clinical Molecular Techniques. 2013;245–59.
Sebastian, S., et al. “Gene rearrangements testing.” Modern Clinical Molecular Techniques, 2013, pp. 245–59. Scival, doi:10.1007/978-1-4614-2170-2-17.
Sebastian S, Du J, Naeem R. Gene rearrangements testing. Modern Clinical Molecular Techniques. 2013;245–259.
Published In
Modern Clinical Molecular Techniques
DOI
Publication Date
2013
Start / End Page
245 / 259