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Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder.

Publication ,  Journal Article
De Bellis, MD; Hooper, SR; Chen, SD; Provenzale, JM; Boyd, BD; Glessner, CE; MacFall, JR; Payne, ME; Rybczynski, R; Woolley, DP
Published in: Development and psychopathology
November 2015

Magnetic resonance imaging studies of maltreated children with posttraumatic stress disorder (PTSD) suggest that maltreatment-related PTSD is associated with adverse brain development. Maltreated youth resilient to chronic PTSD were not previously investigated and may elucidate neuromechanisms of the stress diathesis that leads to resilience to chronic PTSD. In this cross-sectional study, anatomical volumetric and corpus callosum diffusion tensor imaging measures were examined using magnetic resonance imaging in maltreated youth with chronic PTSD (N = 38), without PTSD (N = 35), and nonmaltreated participants (n = 59). Groups were sociodemographically similar. Participants underwent assessments for strict inclusion/exclusion criteria and psychopathology. Maltreated youth with PTSD were psychobiologically different from maltreated youth without PTSD and nonmaltreated controls. Maltreated youth with PTSD had smaller posterior cerebral and cerebellar gray matter volumes than did maltreated youth without PTSD and nonmaltreated participants. Cerebral and cerebellar gray matter volumes inversely correlated with PTSD symptoms. Posterior corpus callosum microstructure in pediatric maltreatment-related PTSD differed compared to maltreated youth without PTSD and controls. The group differences remained significant when controlling for psychopathology, numbers of Axis I disorders, and trauma load. Alterations of these posterior brain structures may result from a shared trauma-related mechanism or an inherent vulnerability that mediates the pathway from chronic PTSD to comorbidity.

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Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

November 2015

Volume

27

Issue

4 Pt 2

Start / End Page

1555 / 1576

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gray Matter
  • Female
  • Diffusion Tensor Imaging
  • Developmental & Child Psychology
  • Cross-Sectional Studies
  • Corpus Callosum
 

Citation

APA
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ICMJE
MLA
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De Bellis, M. D., Hooper, S. R., Chen, S. D., Provenzale, J. M., Boyd, B. D., Glessner, C. E., … Woolley, D. P. (2015). Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. Development and Psychopathology, 27(4 Pt 2), 1555–1576. https://doi.org/10.1017/s0954579415000942
De Bellis, Michael D., Stephen R. Hooper, Steven D. Chen, James M. Provenzale, Brian D. Boyd, Christopher E. Glessner, James R. MacFall, Martha E. Payne, Robert Rybczynski, and Donald P. Woolley. “Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder.Development and Psychopathology 27, no. 4 Pt 2 (November 2015): 1555–76. https://doi.org/10.1017/s0954579415000942.
De Bellis MD, Hooper SR, Chen SD, Provenzale JM, Boyd BD, Glessner CE, et al. Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. Development and psychopathology. 2015 Nov;27(4 Pt 2):1555–76.
De Bellis, Michael D., et al. “Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder.Development and Psychopathology, vol. 27, no. 4 Pt 2, Nov. 2015, pp. 1555–76. Epmc, doi:10.1017/s0954579415000942.
De Bellis MD, Hooper SR, Chen SD, Provenzale JM, Boyd BD, Glessner CE, MacFall JR, Payne ME, Rybczynski R, Woolley DP. Posterior structural brain volumes differ in maltreated youth with and without chronic posttraumatic stress disorder. Development and psychopathology. 2015 Nov;27(4 Pt 2):1555–1576.
Journal cover image

Published In

Development and psychopathology

DOI

EISSN

1469-2198

ISSN

0954-5794

Publication Date

November 2015

Volume

27

Issue

4 Pt 2

Start / End Page

1555 / 1576

Related Subject Headings

  • Stress Disorders, Post-Traumatic
  • Male
  • Magnetic Resonance Imaging
  • Humans
  • Gray Matter
  • Female
  • Diffusion Tensor Imaging
  • Developmental & Child Psychology
  • Cross-Sectional Studies
  • Corpus Callosum