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Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.

Publication ,  Journal Article
Yin, J; Liu, H; Yi, X; Wu, W; Amos, CI; Fang, S; Lee, JE; Han, J; Wei, Q
Published in: Pigment Cell Melanoma Res
March 2016

Single nucleotide polymorphisms (SNPs) in the vitamin D pathway genes have been implicated in cutaneous melanoma (CM) risk, but their role in CM disease-specific survival (DSS) remains obscure. We comprehensively analyzed the prognostic roles of 2669 common SNPs in the vitamin D pathway genes using data from a published genome-wide association study (GWAS) at The University of Texas M.D. Anderson Cancer Center (MDACC) and then validated the SNPs of interest in another GWAS from the Nurses' Health Study and Health Professionals Follow-up Study. Among the 2669 SNPs, 203 were significantly associated with DSS in MDACC dataset (P < 0.05 and false-positive report probability < 0.2), of which 18 were the tag SNPs. In the replication, two of these 18 SNPs showed nominal significance: the VDBP rs12512631 T > C was associated with a better DSS [combined hazards ratio (HR) = 0.66]; and the same for RXRA rs7850212 C > A (combined HR = 0.38), which were further confirmed by the Fine and Gray competing-risks regression model. Further bioinformatics analyses indicated that these loci may modulate corresponding gene methylation status.

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Published In

Pigment Cell Melanoma Res

DOI

EISSN

1755-148X

Publication Date

March 2016

Volume

29

Issue

2

Start / End Page

176 / 185

Location

England

Related Subject Headings

  • Vitamin D-Binding Protein
  • Survival Rate
  • Skin Neoplasms
  • Retinoid X Receptor alpha
  • Polymorphism, Single Nucleotide
  • Neoplasm Proteins
  • Melanoma
  • Male
  • Humans
  • Genome-Wide Association Study
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yin, J., Liu, H., Yi, X., Wu, W., Amos, C. I., Fang, S., … Wei, Q. (2016). Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival. Pigment Cell Melanoma Res, 29(2), 176–185. https://doi.org/10.1111/pcmr.12437
Yin, Jieyun, Hongliang Liu, Xiaohua Yi, Wenting Wu, Christopher I. Amos, Shenying Fang, Jeffrey E. Lee, Jiali Han, and Qingyi Wei. “Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.Pigment Cell Melanoma Res 29, no. 2 (March 2016): 176–85. https://doi.org/10.1111/pcmr.12437.
Yin J, Liu H, Yi X, Wu W, Amos CI, Fang S, et al. Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival. Pigment Cell Melanoma Res. 2016 Mar;29(2):176–85.
Yin, Jieyun, et al. “Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival.Pigment Cell Melanoma Res, vol. 29, no. 2, Mar. 2016, pp. 176–85. Pubmed, doi:10.1111/pcmr.12437.
Yin J, Liu H, Yi X, Wu W, Amos CI, Fang S, Lee JE, Han J, Wei Q. Genetic variants in the vitamin D pathway genes VDBP and RXRA modulate cutaneous melanoma disease-specific survival. Pigment Cell Melanoma Res. 2016 Mar;29(2):176–185.
Journal cover image

Published In

Pigment Cell Melanoma Res

DOI

EISSN

1755-148X

Publication Date

March 2016

Volume

29

Issue

2

Start / End Page

176 / 185

Location

England

Related Subject Headings

  • Vitamin D-Binding Protein
  • Survival Rate
  • Skin Neoplasms
  • Retinoid X Receptor alpha
  • Polymorphism, Single Nucleotide
  • Neoplasm Proteins
  • Melanoma
  • Male
  • Humans
  • Genome-Wide Association Study