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Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes.

Publication ,  Journal Article
Wong, CW; Teo, BW; Lamoureux, E; Ikram, MK; Wang, JJ; Tai, ES; Sethi, S; Wong, TY; Sabanayagam, C
Published in: J Diabetes Res
2015

PURPOSE: We examined the association of CKD defined by serum creatinine, serum cystatin C, and albuminuria with moderate diabetic retinopathy (DR). METHODS: We examined 1,119 Indian adults with diabetes, aged 40-80 years, who participated in the Singapore Indian Eye Study (2007-2009), a population-based cross-sectional study. The associations of CKD defined by each of the three markers alone and in combination with moderate DR were examined using logistic regression models adjusted for potential confounding factors including duration of diabetes, smoking, body mass index, systolic blood pressure, and HbA1c. RESULTS: The prevalence of moderate DR was significantly higher among those with CKD defined by triple markers (41.1%) compared to CKD defined separately by creatinine (26.6%), cystatin C (20.9%), and albuminuria (23.4%). People with CKD defined by triple markers had a fourteenfold higher odds of moderate DR (OR (95% CI) = 13.63 (6.08-30.54)) compared to those without CKD by any marker. Nearly half (48.7%) of participants with cystatin C ≥ 1.12 mg/L have moderate DR. CONCLUSIONS: CKD defined by a triple marker panel was strongly associated with moderate DR in this Asian population with diabetes.

Duke Scholars

Published In

J Diabetes Res

DOI

EISSN

2314-6753

Publication Date

2015

Volume

2015

Start / End Page

404280

Location

England

Related Subject Headings

  • Singapore
  • Risk Factors
  • Renal Insufficiency, Chronic
  • Middle Aged
  • Male
  • Humans
  • Female
  • Diabetic Retinopathy
  • Diabetes Mellitus
  • Cystatin C
 

Citation

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Wong, C. W., Teo, B. W., Lamoureux, E., Ikram, M. K., Wang, J. J., Tai, E. S., … Sabanayagam, C. (2015). Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes. J Diabetes Res, 2015, 404280. https://doi.org/10.1155/2015/404280
Wong, Chee Wai, Boon Wee Teo, Ecosse Lamoureux, Mohammad Kamran Ikram, Jie Jin Wang, E Shyong Tai, Sunil Sethi, Tien Yin Wong, and Charumathi Sabanayagam. “Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes.J Diabetes Res 2015 (2015): 404280. https://doi.org/10.1155/2015/404280.
Wong CW, Teo BW, Lamoureux E, Ikram MK, Wang JJ, Tai ES, et al. Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes. J Diabetes Res. 2015;2015:404280.
Wong, Chee Wai, et al. “Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes.J Diabetes Res, vol. 2015, 2015, p. 404280. Pubmed, doi:10.1155/2015/404280.
Wong CW, Teo BW, Lamoureux E, Ikram MK, Wang JJ, Tai ES, Sethi S, Wong TY, Sabanayagam C. Serum Cystatin C, Markers of Chronic Kidney Disease, and Retinopathy in Persons with Diabetes. J Diabetes Res. 2015;2015:404280.

Published In

J Diabetes Res

DOI

EISSN

2314-6753

Publication Date

2015

Volume

2015

Start / End Page

404280

Location

England

Related Subject Headings

  • Singapore
  • Risk Factors
  • Renal Insufficiency, Chronic
  • Middle Aged
  • Male
  • Humans
  • Female
  • Diabetic Retinopathy
  • Diabetes Mellitus
  • Cystatin C