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Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).

Publication ,  Journal Article
Cho, K-I; Haney, V; Yoon, D; Hao, Y; Ferreira, PA
Published in: FEBS Lett
December 21, 2015

Morphological disintegration of neurons is coupled invariably to neural death. In particular, disruption of outer segments of photoreceptor neurons triggers photoreceptor death regardless of the pathological stressors. We show that Ranbp2(-/-)::Tg-Ranbp2(CLDm-HA) mice with mutations in SUMO-binding motif (SBM) of cyclophilin-like domain (CLD) of Ran-binding protein 2 (Ranbp2) expressed in a null Ranbp2 background lack untoward effects in photoreceptors in the absence of light-stress. However, compared to wild type photoreceptors, light-stress elicits profound disintegration of outer segments of Ranbp2(-/-)::Tg-Ranbp2(CLDm-HA) with paradoxical age-dependent resistance of photoreceptors to death and genotype-independent activation of caspases. Ranbp2(-/-)::Tg-Ranbp2(CLDm-HA) exhibit photoreceptor death-independent changes in ubiquitin-proteasome system (UPS), but death-dependent increase of ubiquitin carrier protein 9(ubc9) levels. Hence, insidious functional impairment of SBM of Ranbp2's CLD promotes neuroprotection and uncoupling of photoreceptor degeneration and death against phototoxicity.

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Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

December 21, 2015

Volume

589

Issue

24 Pt B

Start / End Page

3959 / 3968

Location

England

Related Subject Headings

  • Ubiquitin-Conjugating Enzymes
  • Specific Pathogen-Free Organisms
  • Recombinant Fusion Proteins
  • Proteolysis
  • Protein Interaction Domains and Motifs
  • Proteasome Endopeptidase Complex
  • Photoreceptor Cells, Vertebrate
  • Peptide Fragments
  • Nuclear Pore Complex Proteins
  • Nerve Tissue Proteins
 

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Cho, K.-I., Haney, V., Yoon, D., Hao, Y., & Ferreira, P. A. (2015). Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2). FEBS Lett, 589(24 Pt B), 3959–3968. https://doi.org/10.1016/j.febslet.2015.11.037
Cho, Kyoung-in, Victoria Haney, Dosuk Yoon, Yin Hao, and Paulo A. Ferreira. “Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).FEBS Lett 589, no. 24 Pt B (December 21, 2015): 3959–68. https://doi.org/10.1016/j.febslet.2015.11.037.
Cho, Kyoung-in, et al. “Uncoupling phototoxicity-elicited neural dysmorphology and death by insidious function and selective impairment of Ran-binding protein 2 (Ranbp2).FEBS Lett, vol. 589, no. 24 Pt B, Dec. 2015, pp. 3959–68. Pubmed, doi:10.1016/j.febslet.2015.11.037.
Journal cover image

Published In

FEBS Lett

DOI

EISSN

1873-3468

Publication Date

December 21, 2015

Volume

589

Issue

24 Pt B

Start / End Page

3959 / 3968

Location

England

Related Subject Headings

  • Ubiquitin-Conjugating Enzymes
  • Specific Pathogen-Free Organisms
  • Recombinant Fusion Proteins
  • Proteolysis
  • Protein Interaction Domains and Motifs
  • Proteasome Endopeptidase Complex
  • Photoreceptor Cells, Vertebrate
  • Peptide Fragments
  • Nuclear Pore Complex Proteins
  • Nerve Tissue Proteins