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Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.

Publication ,  Journal Article
Seeds, AM; Tsui, MM; Sunu, C; Spana, EP; York, JD
Published in: Proceedings of the National Academy of Sciences of the United States of America
December 2015

Inositol phosphate kinase 2 (Ipk2), also known as IP multikinase IPMK, is an evolutionarily conserved protein that initiates production of inositol phosphate intracellular messengers (IPs), which are critical for regulating nuclear and cytoplasmic processes. Here we report that Ipk2 kinase activity is required for the development of the adult fruit fly epidermis. Ipk2 mutants show impaired development of their imaginal discs, the primordial tissues that form the adult epidermis. Although disk tissue seems to specify normally during early embryogenesis, loss of Ipk2 activity results in increased apoptosis and impairment of proliferation during larval and pupal development. The proliferation defect is in part attributed to a reduction in JAK/STAT signaling, possibly by controlling production or secretion of the pathway's activating ligand, Unpaired. Constitutive activation of the JAK/STAT pathway downstream of Unpaired partially rescues the disk growth defects in Ipk2 mutants. Thus, IP production is essential for proliferation of the imaginal discs, in part, by regulating JAK/STAT signaling. Our work demonstrates an essential role for Ipk2 in producing inositide messengers required for imaginal disk tissue maturation and subsequent formation of adult body structures and provides molecular insights to signaling pathways involved in tissue growth and stability during development.

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Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

December 2015

Volume

112

Issue

51

Start / End Page

15660 / 15665

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • STAT Transcription Factors
  • Phosphotransferases (Alcohol Group Acceptor)
  • Janus Kinases
  • Imaginal Discs
  • Drosophila melanogaster
  • Drosophila Proteins
  • Cell Proliferation
  • Animals
 

Citation

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Seeds, A. M., Tsui, M. M., Sunu, C., Spana, E. P., & York, J. D. (2015). Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America, 112(51), 15660–15665. https://doi.org/10.1073/pnas.1514684112
Seeds, Andrew M., Marco M. Tsui, Christine Sunu, Eric P. Spana, and John D. York. “Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.Proceedings of the National Academy of Sciences of the United States of America 112, no. 51 (December 2015): 15660–65. https://doi.org/10.1073/pnas.1514684112.
Seeds AM, Tsui MM, Sunu C, Spana EP, York JD. Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec;112(51):15660–5.
Seeds, Andrew M., et al. “Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila.Proceedings of the National Academy of Sciences of the United States of America, vol. 112, no. 51, Dec. 2015, pp. 15660–65. Epmc, doi:10.1073/pnas.1514684112.
Seeds AM, Tsui MM, Sunu C, Spana EP, York JD. Inositol phosphate kinase 2 is required for imaginal disc development in Drosophila. Proceedings of the National Academy of Sciences of the United States of America. 2015 Dec;112(51):15660–15665.
Journal cover image

Published In

Proceedings of the National Academy of Sciences of the United States of America

DOI

EISSN

1091-6490

ISSN

0027-8424

Publication Date

December 2015

Volume

112

Issue

51

Start / End Page

15660 / 15665

Related Subject Headings

  • Transcription Factors
  • Signal Transduction
  • STAT Transcription Factors
  • Phosphotransferases (Alcohol Group Acceptor)
  • Janus Kinases
  • Imaginal Discs
  • Drosophila melanogaster
  • Drosophila Proteins
  • Cell Proliferation
  • Animals