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Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.

Publication ,  Journal Article
Wang, Z; Sturgis, EM; Zhang, F; Lei, D; Liu, Z; Xu, L; Song, X; Wei, Q; Li, G
Published in: Mol Cancer
March 26, 2012

BACKGROUND: Cell cycle deregulation is common in human cancer, and alterations of p27 and p21, two critical cell cycle regulators, have been implicated in the development of many human malignancies. Therefore, we hypothesize that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms modifies risk of second primary malignancy (SPM) in patients with index squamous cell carcinoma of head and neck (SCCHN). METHODS: A cohort of 1,292 patients with index SCCHN was recruited between May 1995 and January 2007 at the M.D. Anderson Cancer Center and followed for SPM occurrence. Patients were genotyped for the three polymorphisms. A log-rank test and Cox proportional hazards models were used to compare SPM-free survival and SPM risk. RESULTS: We found that patients with p27 109 TG/GG, p21 98 CA/AA and p21 70 CT/TT variant genotypes had a worse SPM-free survival and an increased SPM risk than those with the corresponding p27109 TT, p21 98 CC, and p21 70 CC common genotypes, respectively. After combining the three polymorphisms, there was a trend for significantly increased SPM risk with increasing number of the variant genotypes (Ptrend = 0.0002). Moreover, patients with the variant genotypes had an approximately 2.4-fold significantly increased risk for SPM compared with those with no variant genotypes (HR, 2.4, 95% CI, 1.6-3.6). CONCLUSIONS: These results suggest that p27 T109G polymorphism individually or in combination with p21 (C98A and C70T) polymorphisms increases risk of SPM in patients with index SCCHN.

Duke Scholars

Published In

Mol Cancer

DOI

EISSN

1476-4598

Publication Date

March 26, 2012

Volume

11

Start / End Page

17

Location

England

Related Subject Headings

  • Squamous Cell Carcinoma of Head and Neck
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

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Wang, Z., Sturgis, E. M., Zhang, F., Lei, D., Liu, Z., Xu, L., … Li, G. (2012). Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck. Mol Cancer, 11, 17. https://doi.org/10.1186/1476-4598-11-17
Wang, Zhongqiu, Erich M. Sturgis, Fenghua Zhang, Dapeng Lei, Zhensheng Liu, Li Xu, Xicheng Song, Qingyi Wei, and Guojun Li. “Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.Mol Cancer 11 (March 26, 2012): 17. https://doi.org/10.1186/1476-4598-11-17.
Wang, Zhongqiu, et al. “Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.Mol Cancer, vol. 11, Mar. 2012, p. 17. Pubmed, doi:10.1186/1476-4598-11-17.
Wang Z, Sturgis EM, Zhang F, Lei D, Liu Z, Xu L, Song X, Wei Q, Li G. Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck. Mol Cancer. 2012 Mar 26;11:17.

Published In

Mol Cancer

DOI

EISSN

1476-4598

Publication Date

March 26, 2012

Volume

11

Start / End Page

17

Location

England

Related Subject Headings

  • Squamous Cell Carcinoma of Head and Neck
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Neoplasms, Second Primary
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genotype
  • Genetic Predisposition to Disease