Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.

Publication ,  Journal Article
Xu, T; Wei, Q; Lopez Guerra, JL; Wang, L-E; Liu, Z; Gomez, D; O'Reilly, M; Lin, SH; Zhuang, Y; Levy, LB; Mohan, R; Zhou, H; Liao, Z
Published in: Int J Radiat Oncol Biol Phys
October 1, 2012

PURPOSE: We investigated potential associations between single-nucleotide polymorphisms (SNPs) in the heat shock protein beta-1 (HSPB1) gene and overall survival in US patients with non-small cell lung cancer (NSCLC). METHODS AND MATERIALS: Using available genomic DNA samples from 224 patients with NSCLC treated with definitive radio(chemo)therapy, we genotyped 2 SNPs of HSPB1 (NCBI SNP nos. rs2868370 and rs2868371). We used both Kaplan-Meier cumulative probability and Cox proportional hazards analyses to evaluate the effect of HSPB1 genotypes on survival. RESULTS: Our cohort consisted of 117 men and 107 women, mostly white (79.5%), with a median age of 70 years. The median radiation dose was 66 Gy (range, 63-87.5 Gy), and 183 patients (82%) received concurrent platinum-based chemotherapy. The most common genotype of the rs2868371 SNP was CC (61%). Univariate and multivariate analyses showed that this genotype was associated with poorer survival than CG and GG genotypes (univariate hazard ratio [HR] = 1.39, 95% confidence interval [CI], 1.02-1.90; P=.037; multivariate HR = 1.39; 95% CI, 1.01-1.92; P=.045). CONCLUSIONS: Our results showed that the CC genotype of HSPB1 rs2868371 was associated with poorer overall survival in patients with NSCLC after radio(chemo)therapy, findings that contradict those of a previous study of Chinese patients. Validation of our findings with larger numbers of similar patients is needed, as are mechanical and clinical studies to determine the mechanism underlying these associations.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

October 1, 2012

Volume

84

Issue

2

Start / End Page

e229 / e235

Location

United States

Related Subject Headings

  • United States
  • Survival Analysis
  • Risk
  • Reproducibility of Results
  • Radiotherapy Dosage
  • Proportional Hazards Models
  • Probability
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Neoplasm Proteins
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xu, T., Wei, Q., Lopez Guerra, J. L., Wang, L.-E., Liu, Z., Gomez, D., … Liao, Z. (2012). HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer. Int J Radiat Oncol Biol Phys, 84(2), e229–e235. https://doi.org/10.1016/j.ijrobp.2012.03.032
Xu, Ting, Qingyi Wei, Jose Luis Lopez Guerra, Li-E Wang, Zhensheng Liu, Daniel Gomez, Michael O’Reilly, et al. “HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.Int J Radiat Oncol Biol Phys 84, no. 2 (October 1, 2012): e229–35. https://doi.org/10.1016/j.ijrobp.2012.03.032.
Xu T, Wei Q, Lopez Guerra JL, Wang L-E, Liu Z, Gomez D, et al. HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2012 Oct 1;84(2):e229–35.
Xu, Ting, et al. “HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer.Int J Radiat Oncol Biol Phys, vol. 84, no. 2, Oct. 2012, pp. e229–35. Pubmed, doi:10.1016/j.ijrobp.2012.03.032.
Xu T, Wei Q, Lopez Guerra JL, Wang L-E, Liu Z, Gomez D, O’Reilly M, Lin SH, Zhuang Y, Levy LB, Mohan R, Zhou H, Liao Z. HSPB1 gene polymorphisms predict risk of mortality for US patients after radio(chemo)therapy for non-small cell lung cancer. Int J Radiat Oncol Biol Phys. 2012 Oct 1;84(2):e229–e235.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

EISSN

1879-355X

Publication Date

October 1, 2012

Volume

84

Issue

2

Start / End Page

e229 / e235

Location

United States

Related Subject Headings

  • United States
  • Survival Analysis
  • Risk
  • Reproducibility of Results
  • Radiotherapy Dosage
  • Proportional Hazards Models
  • Probability
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Neoplasm Proteins