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Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.

Publication ,  Journal Article
Niu, J; Huang, Y-J; Wei, S; Liu, Z; Wang, L-E; Chang, S; Chamberlain, RM; El-Naggar, AK; Sturgis, EM; Wei, Q
Published in: Head Neck
May 2011

BACKGROUND: To the best of our knowledge, no studies to date have evaluated roles of insulin-like growth factor binding protein 5 (IGFBP5) polymorphisms in risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: A hospital-based study of 1082 patients with SCCHN and 1120 cancer-free controls was performed to investigate associations between 2 functional polymorphisms, -1195T>C and -709G>C, in the IGFBP5 promoter region and SCCHN risk. RESULTS: We demonstrated that the transcription factor, activator protein 1 (AP-1), differentially bound to T or C variants at -1195 in the promoter to regulate the IGFBP5 promoter activity and that the C variant genotypes were associated with deferential risk of late-stage SCCHN, compared to the TT genotype, particularly for human papillomavirus (HPV)-unrelated sites (adjusted odds ratio [OR], 2.21; 95% confidence interval [CI], 1.19-4.11 for CC vs TT). CONCLUSION: The IGFBP5 -1195T>C polymorphism is functional and may potentially be a biomarker for susceptibility to late-stage SCCHN.

Duke Scholars

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

May 2011

Volume

33

Issue

5

Start / End Page

650 / 660

Location

United States

Related Subject Headings

  • Young Adult
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genotype
  • Genetic Predisposition to Disease
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Niu, J., Huang, Y.-J., Wei, S., Liu, Z., Wang, L.-E., Chang, S., … Wei, Q. (2011). Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk. Head Neck, 33(5), 650–660. https://doi.org/10.1002/hed.21514
Niu, Jiangong, Yu-Jing Huang, Sheng Wei, Zhensheng Liu, Li-E Wang, Shine Chang, Robert M. Chamberlain, Adel K. El-Naggar, Erich M. Sturgis, and Qingyi Wei. “Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.Head Neck 33, no. 5 (May 2011): 650–60. https://doi.org/10.1002/hed.21514.
Niu J, Huang Y-J, Wei S, Liu Z, Wang L-E, Chang S, et al. Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk. Head Neck. 2011 May;33(5):650–60.
Niu, Jiangong, et al. “Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk.Head Neck, vol. 33, no. 5, May 2011, pp. 650–60. Pubmed, doi:10.1002/hed.21514.
Niu J, Huang Y-J, Wei S, Liu Z, Wang L-E, Chang S, Chamberlain RM, El-Naggar AK, Sturgis EM, Wei Q. Association between a functional polymorphism (-1195T>C) in the IGFBP5 promoter and head and neck cancer risk. Head Neck. 2011 May;33(5):650–660.

Published In

Head Neck

DOI

EISSN

1097-0347

Publication Date

May 2011

Volume

33

Issue

5

Start / End Page

650 / 660

Location

United States

Related Subject Headings

  • Young Adult
  • Promoter Regions, Genetic
  • Polymorphism, Single Nucleotide
  • Otorhinolaryngology
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genotype
  • Genetic Predisposition to Disease