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A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.

Publication ,  Journal Article
Wei, S; Liu, Z; Zhao, H; Niu, J; Wang, L-E; El-Naggar, AK; Sturgis, EM; Wei, Q
Published in: Cancer
June 15, 2010

BACKGROUND: The authors conducted a hospital-based study of 1110 patients with squamous cell carcinoma of the head and neck (SCCHN) and a control group of 1129 patients to replicate the associations reported by a recent, large European study between 2 potentially functional single nucleotide polymorphisms (SNPs) of the alcohol dehydrogenase (ADH) genes, a substitution in ADH1B at amino acid 48 from arginine to histidine (R48H) (reference SNP number [rs]1229984; guanine to adenine [G-->A]) and a substitution in ADH7 at amino acid 92 from alanine to glycine (A92G) (rs1573496; cytosine to guanine [C-->G]), and the risk of squamous cell carcinoma of the head and neck (SCCHN). METHODS: Multivariate logistic regression was used to calculate adjusted odds ratios (ORs) and 95% confidence intervals (CIs). False-positive report probabilities (FPRPs) also were calculated for significant findings. RESULTS: The ADH7 A92G GG and combined CG + GG genotypes were associated with a decreased risk of SCCHN (GG: adjusted OR, 0.32; 95% CI, 0.13-0.82; CG + GG: adjusted OR, 0.74; 95% CI, 0.59-0.94; FPRP, .098) compared with the CC genotype. This association was also evident in subgroups of older patients (aged >57 years), men, former smokers, patients with oral cancer, and patients with N) lymph node status (P < .05 for all); however, such associations were not observed for the ADH1B R48H SNP. CONCLUSIONS: The current results support the ADH7 A92G SNP as a marker for the risk of SCCHN in non-Hispanic white populations.

Duke Scholars

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

June 15, 2010

Volume

116

Issue

12

Start / End Page

2984 / 2992

Location

United States

Related Subject Headings

  • Smoking
  • Risk
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genetic Predisposition to Disease
  • Female
 

Citation

APA
Chicago
ICMJE
MLA
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Wei, S., Liu, Z., Zhao, H., Niu, J., Wang, L.-E., El-Naggar, A. K., … Wei, Q. (2010). A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck. Cancer, 116(12), 2984–2992. https://doi.org/10.1002/cncr.25058
Wei, Sheng, Zhensheng Liu, Hui Zhao, Jiangong Niu, Li-E Wang, Adel K. El-Naggar, Erich M. Sturgis, and Qingyi Wei. “A single nucleotide polymorphism in the alcohol dehydrogenase 7 gene (alanine to glycine substitution at amino acid 92) is associated with the risk of squamous cell carcinoma of the head and neck.Cancer 116, no. 12 (June 15, 2010): 2984–92. https://doi.org/10.1002/cncr.25058.

Published In

Cancer

DOI

ISSN

0008-543X

Publication Date

June 15, 2010

Volume

116

Issue

12

Start / End Page

2984 / 2992

Location

United States

Related Subject Headings

  • Smoking
  • Risk
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Genetic Predisposition to Disease
  • Female