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Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.

Publication ,  Journal Article
Guan, X; Yin, M; Wei, Q; Zhao, H; Liu, Z; Wang, L-E; Yuan, X; O'Reilly, MS; Komaki, R; Liao, Z
Published in: BMC Cancer
August 16, 2010

BACKGROUND: Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis involving in carcinogenesis, including lung cancer. We hypothesized that VEGF polymorphisms may affect survival outcomes among locally advanced non-small cell lung cancer (LA-NSCLC) patients. METHODS: We genotyped three potentially functional VEGF variants [-460 T > C (rs833061), -634 G > C (rs2010963), and +936 C > T (rs3025039)] and estimated haplotypes in 124 Caucasian patients with LA-NSCLC treated with definitive radiotherapy. We used Kaplan-Meier log-rank tests, and Cox proportional hazard models to evaluate the association between VEGF variants and overall survival (OS). RESULTS: Gender, Karnofsky's performance scores (KPS) and clinical stage seemed to influence the OS. The variant C genotypes were independently associated with significantly improved OS (CT+CC vs. TT: adjusted hazard ratio [HR] = 0.58; 95% confidence interval [CI] = 0.37-0.92, P = 0.022), compared with the VEGF -460 TT genotype. CONCLUSIONS: Our study suggests that VEGF -460 C genotypes may be associated with a better survival of LA-NSCLC patients after chemoradiotherapy. Large studies are needed to confirm our findings.

Duke Scholars

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

August 16, 2010

Volume

10

Start / End Page

431

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Treatment Outcome
  • Survival Rate
  • Radiotherapy Dosage
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms
 

Citation

APA
Chicago
ICMJE
MLA
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Guan, X., Yin, M., Wei, Q., Zhao, H., Liu, Z., Wang, L.-E., … Liao, Z. (2010). Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy. BMC Cancer, 10, 431. https://doi.org/10.1186/1471-2407-10-431
Guan, Xiaoxiang, Ming Yin, Qingyi Wei, Hui Zhao, Zhensheng Liu, Li-E Wang, Xianglin Yuan, Michael S. O’Reilly, Ritsuko Komaki, and Zhongxing Liao. “Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.BMC Cancer 10 (August 16, 2010): 431. https://doi.org/10.1186/1471-2407-10-431.
Guan, Xiaoxiang, et al. “Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy.BMC Cancer, vol. 10, Aug. 2010, p. 431. Pubmed, doi:10.1186/1471-2407-10-431.
Guan X, Yin M, Wei Q, Zhao H, Liu Z, Wang L-E, Yuan X, O’Reilly MS, Komaki R, Liao Z. Genotypes and haplotypes of the VEGF gene and survival in locally advanced non-small cell lung cancer patients treated with chemoradiotherapy. BMC Cancer. 2010 Aug 16;10:431.

Published In

BMC Cancer

DOI

EISSN

1471-2407

Publication Date

August 16, 2010

Volume

10

Start / End Page

431

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Treatment Outcome
  • Survival Rate
  • Radiotherapy Dosage
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Middle Aged
  • Male
  • Lung Neoplasms