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The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.

Publication ,  Journal Article
Li, C; Lu, J; Liu, Z; Wang, L-E; Zhao, H; El-Naggar, AK; Sturgis, EM; Wei, Q
Published in: Cancer Prev Res (Phila)
February 2010

Caspase 8 (CASP8) is an apoptosis-related cysteine peptidase involved in the death receptor pathway and likely in the mitochondrial pathway. A CASP8 promoter region six-nucleotide deletion/insertion (-652 6N ins/del) variant and a coding region D302H polymorphism are reportedly important in cancer development, but no reported study has assessed the associations of these genetic variations with risk of head and neck cancer. In a hospital-based study of non-Hispanic whites, we genotyped CASP8 -652 6N del and 302H variants in 1,023 patients with squamous cell carcinoma of the head and neck (SCCHN) and 1,052 cancer-free controls. Crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) were estimated using unconditional logistic regression models. The CASP8 -652 6N del variant genotypes or haplotypes were inversely associated with SCCHN risk (adjusted OR, 0.70; 95% CI, 0.57-0.85 for the ins/del + del/del genotypes compared with the ins/ins genotype; adjusted OR, 0.73; 95% CI, 0.55-0.97 for the del-D haplotype compared with the ins-D haplotype). Furthermore, the number of the CASP8 -652 6N del (but not 302H) variant allele tended to correlate with increased levels of camptothecin-induced p53-mediated apoptosis in T lymphocytes from 170 cancer-free controls. We concluded that the CASP8 -652 6N del variant allele may contribute to the risk of developing SCCHN in non-Hispanic white populations. Further validation by population-based case-control studies and rigorous mechanistic studies is warranted.

Duke Scholars

Published In

Cancer Prev Res (Phila)

DOI

EISSN

1940-6215

Publication Date

February 2010

Volume

3

Issue

2

Start / End Page

246 / 253

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Sequence Deletion
  • Risk Factors
  • Promoter Regions, Genetic
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mutagenesis, Insertional
  • Middle Aged
  • Male
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Li, C., Lu, J., Liu, Z., Wang, L.-E., Zhao, H., El-Naggar, A. K., … Wei, Q. (2010). The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck. Cancer Prev Res (Phila), 3(2), 246–253. https://doi.org/10.1158/1940-6207.CAPR-08-0228
Li, Chunying, Jiachun Lu, Zhensheng Liu, Li-E Wang, Hui Zhao, Adel K. El-Naggar, Erich M. Sturgis, and Qingyi Wei. “The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.Cancer Prev Res (Phila) 3, no. 2 (February 2010): 246–53. https://doi.org/10.1158/1940-6207.CAPR-08-0228.
Li C, Lu J, Liu Z, Wang L-E, Zhao H, El-Naggar AK, et al. The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck. Cancer Prev Res (Phila). 2010 Feb;3(2):246–53.
Li, Chunying, et al. “The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck.Cancer Prev Res (Phila), vol. 3, no. 2, Feb. 2010, pp. 246–53. Pubmed, doi:10.1158/1940-6207.CAPR-08-0228.
Li C, Lu J, Liu Z, Wang L-E, Zhao H, El-Naggar AK, Sturgis EM, Wei Q. The six-nucleotide deletion/insertion variant in the CASP8 promoter region is inversely associated with risk of squamous cell carcinoma of the head and neck. Cancer Prev Res (Phila). 2010 Feb;3(2):246–253.

Published In

Cancer Prev Res (Phila)

DOI

EISSN

1940-6215

Publication Date

February 2010

Volume

3

Issue

2

Start / End Page

246 / 253

Location

United States

Related Subject Headings

  • T-Lymphocytes
  • Sequence Deletion
  • Risk Factors
  • Promoter Regions, Genetic
  • Oncology & Carcinogenesis
  • Neoplasm Staging
  • Mutagenesis, Insertional
  • Middle Aged
  • Male
  • Humans