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Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.

Publication ,  Journal Article
Neumann, AS; Lyons, HJ; Shen, H; Liu, Z; Shi, Q; Sturgis, EM; Shete, S; Spitz, MR; El-Naggar, A; Hong, WK; Wei, Q
Published in: Int J Cancer
May 20, 2005

Folate deficiency is implicated in cancer risk that may be modulated by a genetic variation in the methylenetetrahydrofolate reductase (MTHFR) gene in folate metabolism. We hypothesized that genetic variants in MTHFR are associated with risk of squamous cell carcinoma of the head and neck (SCCHN). We genotyped 3 MTHFR polymorphisms (C677T, A1298C and G1793A) and estimated their haplotypes in a hospital-based case-control study of 537 SCCHN cases and 545 cancer-free controls. The controls were frequency-matched to the cases by age (+/- 5 years), sex, ethnicity and smoking status. We found that the MTHFR 1298AC/CC genotypes were associated with an approximately 35% reduction in risk of SCCHN (adjusted odds ratio = 0.65; 95% CI = 0.51-0.82) compared to the AA genotype. The MTHFR 677CT and 1793GA/AA genotypes were associated with nonsignificant increased risk of SCCHN compared to the 677CC and 1793GG genotypes, respectively. We estimated that there were 8 haplotypes and 16 haplotype genotypes based on these 3 variants. When we used the haplotypes and assumed that the 677T, 1298A and 1793A alleles were risk alleles, the adjusted odds ratios increased as the number of risk alleles increased: 1.00 for 0-1 variant, 1.85 (1.3-2.5) for any 2 risk alleles and 1.93 (1.4-2.7) for any 3 risk alleles. These results suggest that all 3 MTHFR polymorphisms may play a role in the susceptibility to SCCHN among non-Hispanic whites. Future studies should incorporate detailed data on alcohol consumption, dietary folate intake and related serologic measurements.

Duke Scholars

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

May 20, 2005

Volume

115

Issue

1

Start / End Page

131 / 136

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Haplotypes
 

Citation

APA
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Neumann, A. S., Lyons, H. J., Shen, H., Liu, Z., Shi, Q., Sturgis, E. M., … Wei, Q. (2005). Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer, 115(1), 131–136. https://doi.org/10.1002/ijc.20888
Neumann, Ana S., Heather J. Lyons, Hongbing Shen, Zhensheng Liu, Qiuling Shi, Erich M. Sturgis, Sanjay Shete, et al. “Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.Int J Cancer 115, no. 1 (May 20, 2005): 131–36. https://doi.org/10.1002/ijc.20888.
Neumann AS, Lyons HJ, Shen H, Liu Z, Shi Q, Sturgis EM, et al. Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer. 2005 May 20;115(1):131–6.
Neumann, Ana S., et al. “Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis.Int J Cancer, vol. 115, no. 1, May 2005, pp. 131–36. Pubmed, doi:10.1002/ijc.20888.
Neumann AS, Lyons HJ, Shen H, Liu Z, Shi Q, Sturgis EM, Shete S, Spitz MR, El-Naggar A, Hong WK, Wei Q. Methylenetetrahydrofolate reductase polymorphisms and risk of squamous cell carcinoma of the head and neck: a case-control analysis. Int J Cancer. 2005 May 20;115(1):131–136.
Journal cover image

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

May 20, 2005

Volume

115

Issue

1

Start / End Page

131 / 136

Location

United States

Related Subject Headings

  • Risk Factors
  • Risk
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Middle Aged
  • Methylenetetrahydrofolate Reductase (NADPH2)
  • Male
  • Humans
  • Head and Neck Neoplasms
  • Haplotypes