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Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes.

Publication ,  Journal Article
Edinburgh, KJ; Jasmer, RM; Huang, L; Reddy, GP; Chung, MH; Thompson, A; Halvorsen, RA; Webb, RA
Published in: Radiology
February 2000

PURPOSE: To determine whether the computed tomographic (CT) appearances of multiple pulmonary nodules in patients with acquired immunodeficiency syndrome (AIDS) can help differentiate the potential infectious and neoplastic causes. MATERIALS AND METHODS: The thoracic CT scans obtained in 60 patients with AIDS and multiple pulmonary nodules were reviewed retrospectively by two thoracic radiologists who were blinded to clinical and pathologic data. The scans were evaluated for nodule size, distribution, and morphologic characteristics. CT findings were correlated with final diagnoses. RESULTS: Thirty-six (84%) of 43 patients with opportunistic infection had a predominance of nodules smaller than 1 cm in diameter, whereas 14 (82%) of 17 patients with a neoplasm had a predominance of nodules larger than 1 cm (P <.001). Of the 43 patients with opportunistic infection, 28 (65%) had a centrilobular distribution of nodules; only one (6%) of 17 patients with a neoplasm had this distribution (P <.001). Seven (88%) of eight patients with a peribronchovascular distribution had Kaposi sarcoma (P <.001). CONCLUSION: In patients with AIDS who have multiple pulmonary nodules at CT, nodule size and distribution are useful in the differentiation of potential causes. Nodules smaller than 1 cm, especially those with a centrilobular distribution, are typically infectious. Nodules larger than 1 cm are often neoplastic. A peribronchovascular distribution is suggestive of Kaposi sarcoma.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

February 2000

Volume

214

Issue

2

Start / End Page

427 / 432

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Single-Blind Method
  • Sarcoma, Kaposi
  • Retrospective Studies
  • Respiratory Tract Infections
  • Nuclear Medicine & Medical Imaging
  • Mycobacterium Infections
  • Middle Aged
  • Male
  • Lymphoma, AIDS-Related
 

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Edinburgh, K. J., Jasmer, R. M., Huang, L., Reddy, G. P., Chung, M. H., Thompson, A., … Webb, R. A. (2000). Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes. Radiology, 214(2), 427–432. https://doi.org/10.1148/radiology.214.2.r00fe22427
Edinburgh, K. J., R. M. Jasmer, L. Huang, G. P. Reddy, M. H. Chung, A. Thompson, R. A. Halvorsen, and R. A. Webb. “Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes.Radiology 214, no. 2 (February 2000): 427–32. https://doi.org/10.1148/radiology.214.2.r00fe22427.
Edinburgh KJ, Jasmer RM, Huang L, Reddy GP, Chung MH, Thompson A, et al. Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes. Radiology. 2000 Feb;214(2):427–32.
Edinburgh, K. J., et al. “Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes.Radiology, vol. 214, no. 2, Feb. 2000, pp. 427–32. Pubmed, doi:10.1148/radiology.214.2.r00fe22427.
Edinburgh KJ, Jasmer RM, Huang L, Reddy GP, Chung MH, Thompson A, Halvorsen RA, Webb RA. Multiple pulmonary nodules in AIDS: usefulness of CT in distinguishing among potential causes. Radiology. 2000 Feb;214(2):427–432.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

February 2000

Volume

214

Issue

2

Start / End Page

427 / 432

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Single-Blind Method
  • Sarcoma, Kaposi
  • Retrospective Studies
  • Respiratory Tract Infections
  • Nuclear Medicine & Medical Imaging
  • Mycobacterium Infections
  • Middle Aged
  • Male
  • Lymphoma, AIDS-Related