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Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans.

Publication ,  Journal Article
Sanapareddy, N; Legge, RM; Jovov, B; McCoy, A; Burcal, L; Araujo-Perez, F; Randall, TA; Galanko, J; Benson, A; Sandler, RS; Rawls, JF; Abdo, Z ...
Published in: ISME J
October 2012

Differences in the composition of the gut microbial community have been associated with diseases such as obesity, Crohn's disease, ulcerative colitis and colorectal cancer (CRC). We used 454 titanium pyrosequencing of the V1-V2 region of the 16S rRNA gene to characterize adherent bacterial communities in mucosal biopsy samples from 33 subjects with adenomas and 38 subjects without adenomas (controls). Biopsy samples from subjects with adenomas had greater numbers of bacteria from 87 taxa than controls; only 5 taxa were more abundant in control samples. The magnitude of the differences in the distal gut microbiota between patients with adenomas and controls was more pronounced than that of any other clinical parameters including obesity, diet or family history of CRC. This suggests that sequence analysis of the microbiota could be used to identify patients at risk for developing adenomas.

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Published In

ISME J

DOI

EISSN

1751-7370

Publication Date

October 2012

Volume

6

Issue

10

Start / End Page

1858 / 1868

Location

England

Related Subject Headings

  • Sequence Analysis, DNA
  • Rectum
  • RNA, Ribosomal, 16S
  • Middle Aged
  • Microbiology
  • Metagenome
  • Male
  • Humans
  • Female
  • DNA, Bacterial
 

Citation

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Sanapareddy, N., Legge, R. M., Jovov, B., McCoy, A., Burcal, L., Araujo-Perez, F., … Keku, T. O. (2012). Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME J, 6(10), 1858–1868. https://doi.org/10.1038/ismej.2012.43
Sanapareddy, Nina, Ryan M. Legge, Biljana Jovov, Amber McCoy, Lauren Burcal, Felix Araujo-Perez, Thomas A. Randall, et al. “Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans.ISME J 6, no. 10 (October 2012): 1858–68. https://doi.org/10.1038/ismej.2012.43.
Sanapareddy N, Legge RM, Jovov B, McCoy A, Burcal L, Araujo-Perez F, et al. Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME J. 2012 Oct;6(10):1858–68.
Sanapareddy, Nina, et al. “Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans.ISME J, vol. 6, no. 10, Oct. 2012, pp. 1858–68. Pubmed, doi:10.1038/ismej.2012.43.
Sanapareddy N, Legge RM, Jovov B, McCoy A, Burcal L, Araujo-Perez F, Randall TA, Galanko J, Benson A, Sandler RS, Rawls JF, Abdo Z, Fodor AA, Keku TO. Increased rectal microbial richness is associated with the presence of colorectal adenomas in humans. ISME J. 2012 Oct;6(10):1858–1868.

Published In

ISME J

DOI

EISSN

1751-7370

Publication Date

October 2012

Volume

6

Issue

10

Start / End Page

1858 / 1868

Location

England

Related Subject Headings

  • Sequence Analysis, DNA
  • Rectum
  • RNA, Ribosomal, 16S
  • Middle Aged
  • Microbiology
  • Metagenome
  • Male
  • Humans
  • Female
  • DNA, Bacterial