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Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.

Publication ,  Journal Article
Rawls, JF; Mahowald, MA; Ley, RE; Gordon, JI
Published in: Cell
October 20, 2006

The gut microbiotas of zebrafish and mice share six bacterial divisions, although the specific bacteria within these divisions differ. To test how factors specific to host gut habitat shape microbial community structure, we performed reciprocal transplantations of these microbiotas into germ-free zebrafish and mouse recipients. The results reveal that communities are assembled in predictable ways. The transplanted community resembles its community of origin in terms of the lineages present, but the relative abundance of the lineages changes to resemble the normal gut microbial community composition of the recipient host. Thus, differences in community structure between zebrafish and mice arise in part from distinct selective pressures imposed within the gut habitat of each host. Nonetheless, vertebrate responses to microbial colonization of the gut are ancient: Functional genomic studies disclosed shared host responses to their compositionally distinct microbial communities and distinct microbial species that elicit conserved responses.

Duke Scholars

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

October 20, 2006

Volume

127

Issue

2

Start / End Page

423 / 433

Location

United States

Related Subject Headings

  • Zebrafish
  • Transcription, Genetic
  • Symbiosis
  • Sequence Analysis, RNA
  • Sequence Alignment
  • Selection, Genetic
  • Ribotyping
  • RNA, Ribosomal, 16S
  • RNA, Bacterial
  • Phylogeny
 

Citation

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ICMJE
MLA
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Rawls, J. F., Mahowald, M. A., Ley, R. E., & Gordon, J. I. (2006). Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell, 127(2), 423–433. https://doi.org/10.1016/j.cell.2006.08.043
Rawls, John F., Michael A. Mahowald, Ruth E. Ley, and Jeffrey I. Gordon. “Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.Cell 127, no. 2 (October 20, 2006): 423–33. https://doi.org/10.1016/j.cell.2006.08.043.
Rawls, John F., et al. “Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection.Cell, vol. 127, no. 2, Oct. 2006, pp. 423–33. Pubmed, doi:10.1016/j.cell.2006.08.043.
Rawls JF, Mahowald MA, Ley RE, Gordon JI. Reciprocal gut microbiota transplants from zebrafish and mice to germ-free recipients reveal host habitat selection. Cell. 2006 Oct 20;127(2):423–433.
Journal cover image

Published In

Cell

DOI

ISSN

0092-8674

Publication Date

October 20, 2006

Volume

127

Issue

2

Start / End Page

423 / 433

Location

United States

Related Subject Headings

  • Zebrafish
  • Transcription, Genetic
  • Symbiosis
  • Sequence Analysis, RNA
  • Sequence Alignment
  • Selection, Genetic
  • Ribotyping
  • RNA, Ribosomal, 16S
  • RNA, Bacterial
  • Phylogeny