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Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes.

Publication ,  Journal Article
Rawls, JF; Johnson, SL
Published in: Development
June 2001

Embryonic neural crest-derived melanocytes and their precursors express the kit receptor tyrosine kinase and require its function for their migration and survival. However, mutations in kit also cause deficits in melanocytes that make up adult pigment patterns, including melanocytes that re-establish the zebrafish fin stripes during regeneration. As adult melanocytes in mice and zebrafish are generated and maintained by stem cell populations that are presumably established during embryonic development, it has been proposed that adult phenotypes in kit mutants result from embryonic requirements for kit. We have used a temperature-sensitive zebrafish kit mutation to show that kit is required during adult fin regeneration to promote melanocyte differentiation, rather than during embryonic stages to establish their stem cell precursors. We also demonstrate a transient role for kit in promoting the survival of newly differentiated regeneration melanocytes.

Duke Scholars

Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 2001

Volume

128

Issue

11

Start / End Page

1943 / 1949

Location

England

Related Subject Headings

  • Zebrafish
  • Temperature
  • Proto-Oncogene Proteins c-kit
  • Mutagenesis
  • Melanocytes
  • Cell Survival
  • Cell Division
  • Cell Differentiation
  • Animals
  • 42 Health sciences
 

Citation

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ICMJE
MLA
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Rawls, J. F., & Johnson, S. L. (2001). Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes. Development, 128(11), 1943–1949. https://doi.org/10.1242/dev.128.11.1943
Rawls, J. F., and S. L. Johnson. “Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes.Development 128, no. 11 (June 2001): 1943–49. https://doi.org/10.1242/dev.128.11.1943.
Rawls, J. F., and S. L. Johnson. “Requirements for the kit receptor tyrosine kinase during regeneration of zebrafish fin melanocytes.Development, vol. 128, no. 11, June 2001, pp. 1943–49. Pubmed, doi:10.1242/dev.128.11.1943.
Journal cover image

Published In

Development

DOI

ISSN

0950-1991

Publication Date

June 2001

Volume

128

Issue

11

Start / End Page

1943 / 1949

Location

England

Related Subject Headings

  • Zebrafish
  • Temperature
  • Proto-Oncogene Proteins c-kit
  • Mutagenesis
  • Melanocytes
  • Cell Survival
  • Cell Division
  • Cell Differentiation
  • Animals
  • 42 Health sciences