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Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.

Publication ,  Journal Article
Yu, H; Ma, H; Yin, M; Wei, Q
Published in: Genet Epidemiol
January 2012

Poly(ADP-ribose) polymerase-1 (PARP-1 catalyzes poly(ADP-ribosyl)ation to various proteins involved in many cellular processes, including DNA damage detection and repair and cell proliferation and death. PARP-1 has been implicated in human carcinogenesis, but the association between the most-studied PARP-1 V762A polymorphism (rs1136410) and risk of various cancers was reported with inconclusive results. The aim of this study was to assess the association between the PARP-1 V762A polymorphism and cancer risk. A meta-analysis of 21 studies with 12,027 cancer patients and 14,106 cancer-free controls was conducted to evaluate the strength of the association using odds ratio (OR) with 95% confidence interval (CI). Overall, no significant association was found between the PARP-1 V762A polymorphism and cancer risk. In the stratified analyses, however, it was found that the variant A allele of the PARP-1 V762A polymorphism was associated with an increased risk of cancer among Asian populations (VA + AA vs. VV: OR = 1.11, 95% CI: 1.01-1.23; P(heterogeneity) = 0.210), but a decreased risk of cancer (VA + AA vs. VV: OR = 0.89, 95% CI: 0.80-1.00; P(heterogeneity) = 0.004) among Caucasian populations, especially for glioma risk (OR = 0.79, 95% CI: 0.69-0.90; P(heterogeneity) = 0.800). This meta-analysis found evidence for an association of the PARP-1 V 762A polymorphism with increased risk of cancer among Asians, but decreased risk of cancer among Caucasians, particularly of glioma. Further well-designed studies with large sample sizes of different ethnic populations and different cancer types are warranted to confirm these findings.

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Published In

Genet Epidemiol

DOI

EISSN

1098-2272

Publication Date

January 2012

Volume

36

Issue

1

Start / End Page

56 / 65

Location

United States

Related Subject Headings

  • White People
  • Polymorphism, Genetic
  • Poly(ADP-ribose) Polymerases
  • Poly (ADP-Ribose) Polymerase-1
  • Odds Ratio
  • Neoplasms
  • Humans
  • Genetic Predisposition to Disease
  • Epidemiology
  • Asian People
 

Citation

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Yu, H., Ma, H., Yin, M., & Wei, Q. (2012). Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. Genet Epidemiol, 36(1), 56–65. https://doi.org/10.1002/gepi.20663
Yu, Hongping, Hongxia Ma, Ming Yin, and Qingyi Wei. “Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.Genet Epidemiol 36, no. 1 (January 2012): 56–65. https://doi.org/10.1002/gepi.20663.
Yu H, Ma H, Yin M, Wei Q. Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. Genet Epidemiol. 2012 Jan;36(1):56–65.
Yu, Hongping, et al. “Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis.Genet Epidemiol, vol. 36, no. 1, Jan. 2012, pp. 56–65. Pubmed, doi:10.1002/gepi.20663.
Yu H, Ma H, Yin M, Wei Q. Association between PARP-1 V762A polymorphism and cancer susceptibility: a meta-analysis. Genet Epidemiol. 2012 Jan;36(1):56–65.

Published In

Genet Epidemiol

DOI

EISSN

1098-2272

Publication Date

January 2012

Volume

36

Issue

1

Start / End Page

56 / 65

Location

United States

Related Subject Headings

  • White People
  • Polymorphism, Genetic
  • Poly(ADP-ribose) Polymerases
  • Poly (ADP-Ribose) Polymerase-1
  • Odds Ratio
  • Neoplasms
  • Humans
  • Genetic Predisposition to Disease
  • Epidemiology
  • Asian People