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Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma.

Publication ,  Journal Article
Xu, L; Doan, PC; Wei, Q; Li, G; Sturgis, EM
Published in: Oral Oncol
September 2012

OBJECTIVES: Polymorphic BRCA1 is a vital tumor suppressor gene within the DNA double-strand break repair pathways, but its association with salivary gland carcinoma (SGC) has yet to be investigated. MATERIALS AND METHODS: In a case-control study of 156 SGC patients and 511 controls, we used unconditional logistical regression analyses to investigate the association between SGC risk and seven common functional single-nucleotide polymorphisms (A1988G, A31875G, C33420T, A33921G, A34356G, T43893C and A55298G) in BRCA1. RESULTS: T43893C TC/CC genotype was associated with a reduction of SGC risk (adjusted odds ratio=0.55, 95% CI: 0.38-0.80, Bonferroni-adjusted p=0.011), which was more pronounced in women, non-Hispanic whites, and individuals with a family history of cancer in first-degree relatives. The interaction between T43893C and family history of cancer was significant (p=0.009). The GATGGCG and AACAACA haplotypes, both of which carry the T43893C minor allele, were also associated with reduced SGC risk. CONCLUSION: Our results suggest that polymorphic BRCA1, particularly T43893C polymorphism, may protect against SGC.

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Published In

Oral Oncol

DOI

EISSN

1879-0593

Publication Date

September 2012

Volume

48

Issue

9

Start / End Page

842 / 847

Location

England

Related Subject Headings

  • Salivary Gland Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Genetic Predisposition to Disease
  • Genes, BRCA1
  • Dentistry
  • Case-Control Studies
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Xu, L., Doan, P. C., Wei, Q., Li, G., & Sturgis, E. M. (2012). Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma. Oral Oncol, 48(9), 842–847. https://doi.org/10.1016/j.oraloncology.2012.03.012
Xu, Li, Phi C. Doan, Qingyi Wei, Guojun Li, and Erich M. Sturgis. “Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma.Oral Oncol 48, no. 9 (September 2012): 842–47. https://doi.org/10.1016/j.oraloncology.2012.03.012.
Xu L, Doan PC, Wei Q, Li G, Sturgis EM. Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma. Oral Oncol. 2012 Sep;48(9):842–7.
Xu, Li, et al. “Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma.Oral Oncol, vol. 48, no. 9, Sept. 2012, pp. 842–47. Pubmed, doi:10.1016/j.oraloncology.2012.03.012.
Xu L, Doan PC, Wei Q, Li G, Sturgis EM. Functional single-nucleotide polymorphisms in the BRCA1 gene and risk of salivary gland carcinoma. Oral Oncol. 2012 Sep;48(9):842–847.
Journal cover image

Published In

Oral Oncol

DOI

EISSN

1879-0593

Publication Date

September 2012

Volume

48

Issue

9

Start / End Page

842 / 847

Location

England

Related Subject Headings

  • Salivary Gland Neoplasms
  • Risk Factors
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Humans
  • Genetic Predisposition to Disease
  • Genes, BRCA1
  • Dentistry
  • Case-Control Studies