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Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study.

Publication ,  Journal Article
Wang, L-E; Han, CH; Xiong, P; Bondy, ML; Yu, T-K; Brewster, AM; Shete, S; Arun, BK; Buchholz, TA; Wei, Q
Published in: Breast Cancer Res Treat
April 2012

Hypersensitivity to radiation exposure has been suggested to be a risk factor for the development of breast cancer. In this case-control study of 515 young women (≤ 55 years) with newly diagnosed sporadic breast cancer and 402 cancer-free controls, we examined the radiosensitivity as measured by the frequency of chromatid breaks induced by gamma-radiation exposure in the G2 phase of phytohemagglutinin-stimulated and short-term cultured fresh lymphocytes. We found that the average chromatid breaks per cell from 50 well-spread metaphases were statistically significantly higher in 403 non-Hispanic White breast cancer patients (0.52 ± 0.22) than that in 281 non-Hispanic White controls (0.44 ± 0.16) (P value < 0.001), and in 60 Mexican American breast cancer patients (0.52 ± 0.19) than that in 65 Mexican American controls (0.44 ± 0.16) (P value = 0.021), but the difference was not significant in African Americans (52 cases [0.45 ± 0.16] versus 56 controls [0.47 ± 0.16], P = 0.651). The frequency of chromatid breaks per cell above the median of control subjects was associated with two-fold increased risk for breast cancer in non-Hispanic Whites and Mexican Americans. A dose-response relationship was evident between radiosensitivity and risk for breast cancer (P (trend) < 0.001) in these two ethnic groups. We concluded that gamma-ray-induced mutagen sensitivity may play a role in susceptibility to breast cancer in young non-Hispanic White and Mexican American women.

Duke Scholars

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

April 2012

Volume

132

Issue

3

Start / End Page

1147 / 1155

Location

Netherlands

Related Subject Headings

  • White People
  • Oncology & Carcinogenesis
  • Middle Aged
  • Mexican Americans
  • Lymphocytes
  • Humans
  • Gamma Rays
  • Female
  • Disease Susceptibility
  • DNA Breaks
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wang, L.-E., Han, C. H., Xiong, P., Bondy, M. L., Yu, T.-K., Brewster, A. M., … Wei, Q. (2012). Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. Breast Cancer Res Treat, 132(3), 1147–1155. https://doi.org/10.1007/s10549-011-1940-1
Wang, Li-E, Chan H. Han, Ping Xiong, Melissa L. Bondy, Tse-Kuan Yu, Abenaa M. Brewster, Sanjay Shete, Banu K. Arun, Thomas A. Buchholz, and Qingyi Wei. “Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study.Breast Cancer Res Treat 132, no. 3 (April 2012): 1147–55. https://doi.org/10.1007/s10549-011-1940-1.
Wang L-E, Han CH, Xiong P, Bondy ML, Yu T-K, Brewster AM, et al. Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. Breast Cancer Res Treat. 2012 Apr;132(3):1147–55.
Wang, Li-E., et al. “Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study.Breast Cancer Res Treat, vol. 132, no. 3, Apr. 2012, pp. 1147–55. Pubmed, doi:10.1007/s10549-011-1940-1.
Wang L-E, Han CH, Xiong P, Bondy ML, Yu T-K, Brewster AM, Shete S, Arun BK, Buchholz TA, Wei Q. Gamma-ray-induced mutagen sensitivity and risk of sporadic breast cancer in young women: a case-control study. Breast Cancer Res Treat. 2012 Apr;132(3):1147–1155.

Published In

Breast Cancer Res Treat

DOI

EISSN

1573-7217

Publication Date

April 2012

Volume

132

Issue

3

Start / End Page

1147 / 1155

Location

Netherlands

Related Subject Headings

  • White People
  • Oncology & Carcinogenesis
  • Middle Aged
  • Mexican Americans
  • Lymphocytes
  • Humans
  • Gamma Rays
  • Female
  • Disease Susceptibility
  • DNA Breaks