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Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.

Publication ,  Journal Article
Yin, M; Liao, Z; Yuan, X; Guan, X; O'Reilly, MS; Welsh, J; Wang, L-E; Wei, Q
Published in: Cancer Sci
May 2012

Vascular endothelial growth factor (VEGF) is a major mediator of angiogenesis and lung cancer progression. We hypothesized that VEGF polymorphisms may modulate the risk of radiation pneumonitis (RP) in non-small cell lung cancer (NSCLC) patients treated with definitive radiotherapy. We genotyped three potentially functional VEGF single nucleotide polymorphisms (-460 T > C [rs833061], -634 G > C [rs2010963] and +936 C > T [rs3025039]) and estimated the associations of their genotypes and haplotypes with severe radiation pneumonitis (RP ≥grade 3) in 195 NSCLC patients. We found that the VEGF genotypes of rs2010963 and rs3025039 single nucleotide polymorphisms as well as the -460C/-634G/+936C haplotype were predictors of RP development (adjusted hazard ratio [adjHR] = 2.33, 95% confidence interval [CI], 1.01-5.37, P = 0.047 for CC vs GG genotypes; adjHR = 28.13, 95% CI, 5.24-151.02, P < 0.001 for TT vs CC genotypes; and adjHR = 2.51, 95% CI, 1.27-4.98, P = 0.008 for T-C-T vs C-G-C haplotypes). In addition, there was a trend towards reduced RP risk in patients carrying an increased number of protective VEGF genotypes. Our data suggest that VEGF polymorphisms can modulate the risk of radiation pneumonitis in NSCLC patients treated with definitive radiotherapy. Large and independent studies are needed to confirm our findings.

Duke Scholars

Published In

Cancer Sci

DOI

EISSN

1349-7006

Publication Date

May 2012

Volume

103

Issue

5

Start / End Page

945 / 950

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Risk
  • Radiation Pneumonitis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Yin, M., Liao, Z., Yuan, X., Guan, X., O’Reilly, M. S., Welsh, J., … Wei, Q. (2012). Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy. Cancer Sci, 103(5), 945–950. https://doi.org/10.1111/j.1349-7006.2012.02229.x
Yin, Ming, Zhongxing Liao, Xianglin Yuan, Xiaoxiang Guan, Michael S. O’Reilly, James Welsh, Li-E Wang, and Qingyi Wei. “Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.Cancer Sci 103, no. 5 (May 2012): 945–50. https://doi.org/10.1111/j.1349-7006.2012.02229.x.
Yin, Ming, et al. “Polymorphisms of the vascular endothelial growth factor gene and severe radiation pneumonitis in non-small cell lung cancer patients treated with definitive radiotherapy.Cancer Sci, vol. 103, no. 5, May 2012, pp. 945–50. Pubmed, doi:10.1111/j.1349-7006.2012.02229.x.

Published In

Cancer Sci

DOI

EISSN

1349-7006

Publication Date

May 2012

Volume

103

Issue

5

Start / End Page

945 / 950

Location

England

Related Subject Headings

  • Vascular Endothelial Growth Factor A
  • Risk
  • Radiation Pneumonitis
  • Polymorphism, Single Nucleotide
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genotype