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Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.

Publication ,  Journal Article
Nan, H; Xu, M; Zhang, J; Zhang, M; Kraft, P; Qureshi, AA; Chen, C; Guo, Q; Hu, FB; Rimm, EB; Curhan, G; Song, Y; Amos, CI; Wang, L-E ...
Published in: Hum Mol Genet
July 1, 2011

We conducted a genome-wide association study on the number of melanocytic nevi reported by 9136 individuals of European ancestry, with follow-up replication in 3581 individuals. We identified the nidogen 1 (NID1) gene on 1q42 associated with nevus count (two linked single nucleotide polymorphisms with r(2) > 0.9: rs3768080 A allele associated with reduced count, P = 6.5 × 10(-8); and rs10754833 T allele associated with reduced count, P = 1.5 × 10(-7)). We further determined that the rs10754833 [T] was associated with a decreased melanoma risk in 2368 melanoma cases and 7432 controls [for CT genotype: odds ratio (OR) = 0.86, 95% confidence interval (CI) = 0.75-0.99, P = 0.04; for TT genotype: OR = 0.84, 95% CI = 0.71-0.98, P = 0.03]. Expression level of the NID1 locus was 2-fold higher for the rs10754833 T allele carriers than that with the CC genotype (P = 0.017) in the 87 HapMap CEU cell lines. The NID1 gene is a biologically plausible locus for nevogenesis and melanoma development, with decreased expression levels of NID1 in benign nevi (P = 3.5 × 10(-6)) and in primary melanoma (P = 4.6 × 10(-4)) compared with the normal skin.

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Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

July 1, 2011

Volume

20

Issue

13

Start / End Page

2673 / 2679

Location

England

Related Subject Headings

  • Skin Neoplasms
  • Risk
  • Polymorphism, Single Nucleotide
  • Nevus, Pigmented
  • Middle Aged
  • Membrane Glycoproteins
  • Melanoma
  • Male
  • Humans
  • Genotype
 

Citation

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Nan, H., Xu, M., Zhang, J., Zhang, M., Kraft, P., Qureshi, A. A., … Han, J. (2011). Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. Hum Mol Genet, 20(13), 2673–2679. https://doi.org/10.1093/hmg/ddr154
Nan, Hongmei, Mousheng Xu, Jiangwen Zhang, Mingfeng Zhang, Peter Kraft, Abrar A. Qureshi, Constance Chen, et al. “Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.Hum Mol Genet 20, no. 13 (July 1, 2011): 2673–79. https://doi.org/10.1093/hmg/ddr154.
Nan H, Xu M, Zhang J, Zhang M, Kraft P, Qureshi AA, et al. Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. Hum Mol Genet. 2011 Jul 1;20(13):2673–9.
Nan, Hongmei, et al. “Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.Hum Mol Genet, vol. 20, no. 13, July 2011, pp. 2673–79. Pubmed, doi:10.1093/hmg/ddr154.
Nan H, Xu M, Zhang J, Zhang M, Kraft P, Qureshi AA, Chen C, Guo Q, Hu FB, Rimm EB, Curhan G, Song Y, Amos CI, Wang L-E, Lee JE, Wei Q, Hunter DJ, Han J. Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk. Hum Mol Genet. 2011 Jul 1;20(13):2673–2679.

Published In

Hum Mol Genet

DOI

EISSN

1460-2083

Publication Date

July 1, 2011

Volume

20

Issue

13

Start / End Page

2673 / 2679

Location

England

Related Subject Headings

  • Skin Neoplasms
  • Risk
  • Polymorphism, Single Nucleotide
  • Nevus, Pigmented
  • Middle Aged
  • Membrane Glycoproteins
  • Melanoma
  • Male
  • Humans
  • Genotype