Skip to main content
construction release_alert
Scholars@Duke will be undergoing maintenance April 11-15. Some features may be unavailable during this time.
cancel
Journal cover image

Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.

Publication ,  Journal Article
Wassenaar, CA; Dong, Q; Wei, Q; Amos, CI; Spitz, MR; Tyndale, RF
Published in: J Natl Cancer Inst
September 7, 2011

Genetic variations in the CYP2A6 nicotine metabolic gene and the CHRNA5-CHRNA3-CHRNB4 (CHRNA5-A3-B4) nicotinic gene cluster have been independently associated with lung cancer. With genotype data from ever-smokers of European ancestry (417 lung cancer patients and 443 control subjects), we investigated the relative and combined associations of polymorphisms in these two genes with smoking behavior and lung cancer risk. Kruskal-Wallis tests were used to compare smoking variables among the different genotype groups, and odds ratios (ORs) for cancer risk were estimated using logistic regression analysis. All statistical tests were two-sided. Cigarette consumption (P < .001) and nicotine dependence (P = .036) were the highest in the combined CYP2A6 normal metabolizers and CHRNA5-A3-B4 AA (tag single-nucleotide polymorphism rs1051730 G>A) risk group. The combined risk group also exhibited the greatest lung cancer risk (OR = 2.03; 95% confidence interval [CI] = 1.21 to 3.40), which was even higher among those who smoked 20 or fewer cigarettes per day (OR = 3.03; 95% CI = 1.38 to 6.66). Variation in CYP2A6 and CHRNA5-A3-B4 was independently and additively associated with increased cigarette consumption, nicotine dependence, and lung cancer risk. CYP2A6 and CHRNA5-A3-B4 appear to be more strongly associated with smoking behaviors and lung cancer risk, respectively.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

September 7, 2011

Volume

103

Issue

17

Start / End Page

1342 / 1346

Location

United States

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Smoking
  • Risk Factors
  • Risk Assessment
  • Receptors, Nicotinic
  • Oncology & Carcinogenesis
  • Nitrosamines
  • Nerve Tissue Proteins
  • Multigene Family
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Wassenaar, C. A., Dong, Q., Wei, Q., Amos, C. I., Spitz, M. R., & Tyndale, R. F. (2011). Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. J Natl Cancer Inst, 103(17), 1342–1346. https://doi.org/10.1093/jnci/djr237
Wassenaar, Catherine A., Qiong Dong, Qingyi Wei, Christopher I. Amos, Margaret R. Spitz, and Rachel F. Tyndale. “Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.J Natl Cancer Inst 103, no. 17 (September 7, 2011): 1342–46. https://doi.org/10.1093/jnci/djr237.
Wassenaar CA, Dong Q, Wei Q, Amos CI, Spitz MR, Tyndale RF. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. J Natl Cancer Inst. 2011 Sep 7;103(17):1342–6.
Wassenaar, Catherine A., et al. “Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk.J Natl Cancer Inst, vol. 103, no. 17, Sept. 2011, pp. 1342–46. Pubmed, doi:10.1093/jnci/djr237.
Wassenaar CA, Dong Q, Wei Q, Amos CI, Spitz MR, Tyndale RF. Relationship between CYP2A6 and CHRNA5-CHRNA3-CHRNB4 variation and smoking behaviors and lung cancer risk. J Natl Cancer Inst. 2011 Sep 7;103(17):1342–1346.
Journal cover image

Published In

J Natl Cancer Inst

DOI

EISSN

1460-2105

Publication Date

September 7, 2011

Volume

103

Issue

17

Start / End Page

1342 / 1346

Location

United States

Related Subject Headings

  • White People
  • Surveys and Questionnaires
  • Smoking
  • Risk Factors
  • Risk Assessment
  • Receptors, Nicotinic
  • Oncology & Carcinogenesis
  • Nitrosamines
  • Nerve Tissue Proteins
  • Multigene Family