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Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk.

Publication ,  Journal Article
Marron, M; Boffetta, P; Zhang, Z-F; Zaridze, D; Wünsch-Filho, V; Winn, DM; Wei, Q; Talamini, R; Szeszenia-Dabrowska, N; Sturgis, EM; Smith, E ...
Published in: Int J Epidemiol
February 2010

BACKGROUND: Quitting tobacco or alcohol use has been reported to reduce the head and neck cancer risk in previous studies. However, it is unclear how many years must pass following cessation of these habits before the risk is reduced, and whether the risk ultimately declines to the level of never smokers or never drinkers. METHODS: We pooled individual-level data from case-control studies in the International Head and Neck Cancer Epidemiology Consortium. Data were available from 13 studies on drinking cessation (9167 cases and 12 593 controls), and from 17 studies on smoking cessation (12 040 cases and 16 884 controls). We estimated the effect of quitting smoking and drinking on the risk of head and neck cancer and its subsites, by calculating odds ratios (ORs) using logistic regression models. RESULTS: Quitting tobacco smoking for 1-4 years resulted in a head and neck cancer risk reduction [OR 0.70, confidence interval (CI) 0.61-0.81 compared with current smoking], with the risk reduction due to smoking cessation after > or =20 years (OR 0.23, CI 0.18-0.31), reaching the level of never smokers. For alcohol use, a beneficial effect on the risk of head and neck cancer was only observed after > or =20 years of quitting (OR 0.60, CI 0.40-0.89 compared with current drinking), reaching the level of never drinkers. CONCLUSIONS: Our results support that cessation of tobacco smoking and cessation of alcohol drinking protect against the development of head and neck cancer.

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Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

February 2010

Volume

39

Issue

1

Start / End Page

182 / 196

Location

England

Related Subject Headings

  • Time Factors
  • Socioeconomic Factors
  • Smoking Cessation
  • Sex Factors
  • Risk Reduction Behavior
  • Risk
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms
 

Citation

APA
Chicago
ICMJE
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Marron, M., Boffetta, P., Zhang, Z.-F., Zaridze, D., Wünsch-Filho, V., Winn, D. M., … Hashibe, M. (2010). Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol, 39(1), 182–196. https://doi.org/10.1093/ije/dyp291
Marron, Manuela, Paolo Boffetta, Zuo-Feng Zhang, David Zaridze, Victor Wünsch-Filho, Deborah M. Winn, Qingyi Wei, et al. “Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk.Int J Epidemiol 39, no. 1 (February 2010): 182–96. https://doi.org/10.1093/ije/dyp291.
Marron M, Boffetta P, Zhang Z-F, Zaridze D, Wünsch-Filho V, Winn DM, et al. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol. 2010 Feb;39(1):182–96.
Marron, Manuela, et al. “Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk.Int J Epidemiol, vol. 39, no. 1, Feb. 2010, pp. 182–96. Pubmed, doi:10.1093/ije/dyp291.
Marron M, Boffetta P, Zhang Z-F, Zaridze D, Wünsch-Filho V, Winn DM, Wei Q, Talamini R, Szeszenia-Dabrowska N, Sturgis EM, Smith E, Schwartz SM, Rudnai P, Purdue MP, Olshan AF, Eluf-Neto J, Muscat J, Morgenstern H, Menezes A, McClean M, Matos E, Mates IN, Lissowska J, Levi F, Lazarus P, La Vecchia C, Koifman S, Kelsey K, Herrero R, Hayes RB, Franceschi S, Fernandez L, Fabianova E, Daudt AW, Dal Maso L, Curado MP, Cadoni G, Chen C, Castellsague X, Boccia S, Benhamou S, Ferro G, Berthiller J, Brennan P, Møller H, Hashibe M. Cessation of alcohol drinking, tobacco smoking and the reversal of head and neck cancer risk. Int J Epidemiol. 2010 Feb;39(1):182–196.
Journal cover image

Published In

Int J Epidemiol

DOI

EISSN

1464-3685

Publication Date

February 2010

Volume

39

Issue

1

Start / End Page

182 / 196

Location

England

Related Subject Headings

  • Time Factors
  • Socioeconomic Factors
  • Smoking Cessation
  • Sex Factors
  • Risk Reduction Behavior
  • Risk
  • Middle Aged
  • Male
  • Humans
  • Head and Neck Neoplasms