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Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction.

Publication ,  Journal Article
Zevallos, JP; Hanasono, MM; Li, G; Wei, Q; Sturgis, EM
Published in: Arch Facial Plast Surg
2010

BACKGROUND: Glutathione-S-transferase (GST) enzymes play a role in scavenging endogenous oxidants. Altered enzyme activity results from inherited polymorphisms, which results in increased oxidative stress. This study explores the role of GST polymorphisms as modifiers of surgical complications in patients undergoing head and neck microvascular reconstruction. METHODS: Patients newly diagnosed as having head and neck cancer and undergoing microvascular reconstruction were selected. Polymerase chain reaction was used to determine GST genotypes. Demographic factors, treatment, and postoperative complications were reviewed. Multivariate logistic regression analysis was used to estimate the risk of surgical complications associated with variant genotypes. RESULTS: A total of 107 patients were evaluated. Surgical and medical complication rates were 44.9% and 25.2%, respectively. The variant Val allele at the GSTP1 105 codon was associated with a significantly increased risk of surgical complications (P = .046; adjusted relative risk, 1.7; 95% confidence interval, 1.1-2.6). There was no significant association between the other GST variant genotypes and surgical complications. No association was noted between variant GST genotypes and the risk of medical complications. CONCLUSION: GSTP1 codon 105 polymorphism may be a marker for risk of wound complications in head and neck microvascular reconstruction.

Duke Scholars

Published In

Arch Facial Plast Surg

DOI

EISSN

1538-3660

Publication Date

2010

Volume

12

Issue

6

Start / End Page

373 / 378

Location

United States

Related Subject Headings

  • Wound Healing
  • Surgical Flaps
  • Risk Factors
  • Polymorphism, Genetic
  • Plastic Surgery Procedures
  • Oxidative Stress
  • Otorhinolaryngology
  • Middle Aged
  • Microsurgery
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Zevallos, J. P., Hanasono, M. M., Li, G., Wei, Q., & Sturgis, E. M. (2010). Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction. Arch Facial Plast Surg, 12(6), 373–378. https://doi.org/10.1001/archfacial.2010.88
Zevallos, Jose P., Matthew M. Hanasono, Guojun Li, Qingyi Wei, and Erich M. Sturgis. “Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction.Arch Facial Plast Surg 12, no. 6 (2010): 373–78. https://doi.org/10.1001/archfacial.2010.88.
Zevallos JP, Hanasono MM, Li G, Wei Q, Sturgis EM. Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction. Arch Facial Plast Surg. 2010;12(6):373–8.
Zevallos, Jose P., et al. “Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction.Arch Facial Plast Surg, vol. 12, no. 6, 2010, pp. 373–78. Pubmed, doi:10.1001/archfacial.2010.88.
Zevallos JP, Hanasono MM, Li G, Wei Q, Sturgis EM. Glutathione-S-transferase polymorphisms and complications of microvascular head and neck reconstruction. Arch Facial Plast Surg. 2010;12(6):373–378.

Published In

Arch Facial Plast Surg

DOI

EISSN

1538-3660

Publication Date

2010

Volume

12

Issue

6

Start / End Page

373 / 378

Location

United States

Related Subject Headings

  • Wound Healing
  • Surgical Flaps
  • Risk Factors
  • Polymorphism, Genetic
  • Plastic Surgery Procedures
  • Oxidative Stress
  • Otorhinolaryngology
  • Middle Aged
  • Microsurgery
  • Male