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ERCC6/CSB gene polymorphisms and lung cancer risk.

Publication ,  Journal Article
Ma, H; Hu, Z; Wang, H; Jin, G; Wang, Y; Sun, W; Chen, D; Tian, T; Jin, L; Wei, Q; Lu, D; Huang, W; Shen, H
Published in: Cancer Lett
January 8, 2009

Nucleotide excision repair (NER) enzymes are critical for the removal of bulky DNA adducts caused by environmental carcinogens such as smoking. Of them, Cockayne syndrome complementation group B (CSB), coded by ERCC6, recruits NER repair factors to the DNA damage site and plays an important role in the repair process. Genetic variants of ERCC6 may alter the regulation of DNA repair and therefore were hypothesized to be associated with altered risk of smoking-related lung cancer. To test this hypothesis, we genotyped eight tagging single nucleotide polymorphisms (tSNPs) and three potentially functional SNPs of ERCC6 in 500 incident lung cancer cases and 517 controls in a Chinese population. Single locus analyses showed that none of the single SNP alone had the significant main affect on the risk of lung cancer. However, the combined variant genotypes of the four loci with P(trend) approaching to 0.10 (rs2228526, rs4253160, rs12571445 and rs3793784) were associated with a significantly increased lung cancer risk (adjusted OR 1.35, 95% CI, 1.04-1.75 among subjects carrying three or more variant alleles), indicating that multiple loci in ERCC6 may jointly contribute to the susceptibility of lung cancer. These findings, if validated, may contribute to identify at-risk subjects in the general population for smoking-related lung cancer.

Duke Scholars

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Published In

Cancer Lett

DOI

EISSN

1872-7980

Publication Date

January 8, 2009

Volume

273

Issue

1

Start / End Page

172 / 176

Location

Ireland

Related Subject Headings

  • Smoking
  • Risk Factors
  • Polymorphism, Genetic
  • Poly-ADP-Ribose Binding Proteins
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genetic Predisposition to Disease
 

Citation

APA
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Ma, H., Hu, Z., Wang, H., Jin, G., Wang, Y., Sun, W., … Shen, H. (2009). ERCC6/CSB gene polymorphisms and lung cancer risk. Cancer Lett, 273(1), 172–176. https://doi.org/10.1016/j.canlet.2008.08.002
Ma, Hongxia, Zhibin Hu, Haifeng Wang, Guangfu Jin, Ying Wang, Weiwei Sun, Dan Chen, et al. “ERCC6/CSB gene polymorphisms and lung cancer risk.Cancer Lett 273, no. 1 (January 8, 2009): 172–76. https://doi.org/10.1016/j.canlet.2008.08.002.
Ma H, Hu Z, Wang H, Jin G, Wang Y, Sun W, et al. ERCC6/CSB gene polymorphisms and lung cancer risk. Cancer Lett. 2009 Jan 8;273(1):172–6.
Ma, Hongxia, et al. “ERCC6/CSB gene polymorphisms and lung cancer risk.Cancer Lett, vol. 273, no. 1, Jan. 2009, pp. 172–76. Pubmed, doi:10.1016/j.canlet.2008.08.002.
Ma H, Hu Z, Wang H, Jin G, Wang Y, Sun W, Chen D, Tian T, Jin L, Wei Q, Lu D, Huang W, Shen H. ERCC6/CSB gene polymorphisms and lung cancer risk. Cancer Lett. 2009 Jan 8;273(1):172–176.

Published In

Cancer Lett

DOI

EISSN

1872-7980

Publication Date

January 8, 2009

Volume

273

Issue

1

Start / End Page

172 / 176

Location

Ireland

Related Subject Headings

  • Smoking
  • Risk Factors
  • Polymorphism, Genetic
  • Poly-ADP-Ribose Binding Proteins
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Lung Neoplasms
  • Humans
  • Genetic Predisposition to Disease