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Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies.

Publication ,  Journal Article
Lubin, JH; Purdue, M; Kelsey, K; Zhang, Z-F; Winn, D; Wei, Q; Talamini, R; Szeszenia-Dabrowska, N; Sturgis, EM; Smith, E; Shangina, O; Levi, F ...
Published in: Am J Epidemiol
October 15, 2009

Although cigarette smoking and alcohol consumption increase risk for head and neck cancers, there have been few attempts to model risks quantitatively and to formally evaluate cancer site-specific risks. The authors pooled data from 15 case-control studies and modeled the excess odds ratio (EOR) to assess risk by total exposure (pack-years and drink-years) and its modification by exposure rate (cigarettes/day and drinks/day). The smoking analysis included 1,761 laryngeal, 2,453 pharyngeal, and 1,990 oral cavity cancers, and the alcohol analysis included 2,551 laryngeal, 3,693 pharyngeal, and 3,116 oval cavity cancers, with over 8,000 controls. Above 15 cigarettes/day, the EOR/pack-year decreased with increasing cigarettes/day, suggesting that greater cigarettes/day for a shorter duration was less deleterious than fewer cigarettes/day for a longer duration. Estimates of EOR/pack-year were homogeneous across sites, while the effects of cigarettes/day varied, indicating that the greater laryngeal cancer risk derived from differential cigarettes/day effects and not pack-years. EOR/drink-year estimates increased through 10 drinks/day, suggesting that greater drinks/day for a shorter duration was more deleterious than fewer drinks/day for a longer duration. Above 10 drinks/day, data were limited. EOR/drink-year estimates varied by site, while drinks/day effects were homogeneous, indicating that the greater pharyngeal/oral cavity cancer risk with alcohol consumption derived from the differential effects of drink-years and not drinks/day.

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Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

October 15, 2009

Volume

170

Issue

8

Start / End Page

937 / 947

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Pharyngeal Neoplasms
  • Odds Ratio
  • Mouth Neoplasms
  • Laryngeal Neoplasms
  • Humans
  • Head and Neck Neoplasms
  • Epidemiology
  • Case-Control Studies
 

Citation

APA
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Lubin, J. H., Purdue, M., Kelsey, K., Zhang, Z.-F., Winn, D., Wei, Q., … Hayes, R. B. (2009). Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies. Am J Epidemiol, 170(8), 937–947. https://doi.org/10.1093/aje/kwp222
Lubin, Jay H., Mark Purdue, Karl Kelsey, Zuo-Feng Zhang, Debbie Winn, Qingyi Wei, Renato Talamini, et al. “Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies.Am J Epidemiol 170, no. 8 (October 15, 2009): 937–47. https://doi.org/10.1093/aje/kwp222.
Lubin JH, Purdue M, Kelsey K, Zhang Z-F, Winn D, Wei Q, et al. Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies. Am J Epidemiol. 2009 Oct 15;170(8):937–47.
Lubin, Jay H., et al. “Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies.Am J Epidemiol, vol. 170, no. 8, Oct. 2009, pp. 937–47. Pubmed, doi:10.1093/aje/kwp222.
Lubin JH, Purdue M, Kelsey K, Zhang Z-F, Winn D, Wei Q, Talamini R, Szeszenia-Dabrowska N, Sturgis EM, Smith E, Shangina O, Schwartz SM, Rudnai P, Neto JE, Muscat J, Morgenstern H, Menezes A, Matos E, Mates IN, Lissowska J, Levi F, Lazarus P, La Vecchia C, Koifman S, Herrero R, Franceschi S, Wünsch-Filho V, Fernandez L, Fabianova E, Daudt AW, Maso LD, Curado MP, Chen C, Castellsague X, Brennan P, Boffetta P, Hashibe M, Hayes RB. Total exposure and exposure rate effects for alcohol and smoking and risk of head and neck cancer: a pooled analysis of case-control studies. Am J Epidemiol. 2009 Oct 15;170(8):937–947.

Published In

Am J Epidemiol

DOI

EISSN

1476-6256

Publication Date

October 15, 2009

Volume

170

Issue

8

Start / End Page

937 / 947

Location

United States

Related Subject Headings

  • Smoking
  • Risk Factors
  • Pharyngeal Neoplasms
  • Odds Ratio
  • Mouth Neoplasms
  • Laryngeal Neoplasms
  • Humans
  • Head and Neck Neoplasms
  • Epidemiology
  • Case-Control Studies