Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.
Publication
, Journal Article
Zhao, Y; Wang, L; Shen, H-B; Wang, Z-X; Wei, Q-Y; Chen, F
Published in: J Toxicol Environ Health A
December 2007
A meta-regression analysis was undertaken to evaluate the association between delta-aminolevulinic acid dehydratase (ALAD) genotypes and blood lead levels obtained from data published in various journals. In total, 15 studies were included in the final analysis. Both fixed effects and random effects models were used to undertake the pooled analysis. Using a fixed effects model, pooled estimates of mean differences of various ALAD genotypes was significant at 0.61 microg/dl. Using a random effects model, the pooled estimate was also significant at 1.51 microg/dl. Data indicated that certain ALAD genotypes may affect the susceptibility of humans to lead.
Duke Scholars
Published In
J Toxicol Environ Health A
DOI
ISSN
1528-7394
Publication Date
December 2007
Volume
70
Issue
23
Start / End Page
1986 / 1994
Location
England
Related Subject Headings
- Toxicology
- Regression Analysis
- Porphobilinogen Synthase
- Polymorphism, Single Nucleotide
- Occupational Exposure
- Lead Poisoning
- Lead
- Humans
- Environmental Exposure
- Child
Citation
APA
Chicago
ICMJE
MLA
NLM
Zhao, Y., Wang, L., Shen, H.-B., Wang, Z.-X., Wei, Q.-Y., & Chen, F. (2007). Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A, 70(23), 1986–1994. https://doi.org/10.1080/15287390701550946
Zhao, Yang, Lu Wang, Hong-Bing Shen, Zhong-Xu Wang, Qing-Yi Wei, and Feng Chen. “Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.” J Toxicol Environ Health A 70, no. 23 (December 2007): 1986–94. https://doi.org/10.1080/15287390701550946.
Zhao Y, Wang L, Shen H-B, Wang Z-X, Wei Q-Y, Chen F. Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A. 2007 Dec;70(23):1986–94.
Zhao, Yang, et al. “Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis.” J Toxicol Environ Health A, vol. 70, no. 23, Dec. 2007, pp. 1986–94. Pubmed, doi:10.1080/15287390701550946.
Zhao Y, Wang L, Shen H-B, Wang Z-X, Wei Q-Y, Chen F. Association between delta-aminolevulinic acid dehydratase (ALAD) polymorphism and blood lead levels: a meta-regression analysis. J Toxicol Environ Health A. 2007 Dec;70(23):1986–1994.
Published In
J Toxicol Environ Health A
DOI
ISSN
1528-7394
Publication Date
December 2007
Volume
70
Issue
23
Start / End Page
1986 / 1994
Location
England
Related Subject Headings
- Toxicology
- Regression Analysis
- Porphobilinogen Synthase
- Polymorphism, Single Nucleotide
- Occupational Exposure
- Lead Poisoning
- Lead
- Humans
- Environmental Exposure
- Child