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Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.

Publication ,  Journal Article
Liu, J; Zhai, X; Jin, G; Hu, Z; Wang, S; Wang, X; Qin, J; Gao, J; Ma, H; Wang, X; Wei, Q; Shen, H
Published in: Int J Cancer
May 15, 2006

Interleukin 1beta (IL-1beta) is a multifunctional cytokine that upregulates the inflammatory response, and participates in carcinogenesis, malignant transformation, tumor growth, invasion and metastasis. Two potentially functional polymorphisms (T-31C and C-511T) in the IL-1beta gene promoter were suggested to be correlated with alteration of IL-1beta expression and therefore may be associated with cancer risk. To test the hypothesis that these 2 polymorphisms are associated with risk of breast cancer, we performed a case-control study of 365 breast cancer cases, 270 patients with benign breast diseases (BBD) and 631 cancer-free controls in a Chinese population. Multivariate logistic regression analyses revealed that increased risk of breast cancer was associated with IL-1beta-31C variant genotypes [adjusted odds ratio (OR)=1.28 and 95% confidence interval (CI)=0.91-1.80 for -31CT and 1.72 (95% CI=1.16-2.54) for -31CC], compared with the -31TT genotype. Similarly, IL-1beta-511T variant genotypes were also associated with increased risk of breast cancer (adjusted OR=1.20, 95% CI=0.86-1.67 for -511CT and adjusted OR=1.74, 95% CI=1.18-2.56 for -511TT), compared with the -511CC genotype. Furthermore, cancer risks associated with IL-1betaT-31C variant genotypes were more evident in older women, postmenopausal women and individuals with a later menarche age. Interestingly, although we did not find significant associations of these 2 variants with cancer risk when compared with the BBD patients, a 1.27-fold (95% CI=1.01-1.60) increased risk was observed with the -31C-511T common haplotype. These findings indicate that these 2 IL-1beta promoter variants may contribute to risk of developing breast cancer in the Chinese population.

Duke Scholars

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

May 15, 2006

Volume

118

Issue

10

Start / End Page

2554 / 2558

Location

United States

Related Subject Headings

  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Interleukin-1
  • Humans
  • Genotype
  • Female
 

Citation

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MLA
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Liu, J., Zhai, X., Jin, G., Hu, Z., Wang, S., Wang, X., … Shen, H. (2006). Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population. Int J Cancer, 118(10), 2554–2558. https://doi.org/10.1002/ijc.21652
Liu, Jiyong, Xiangjun Zhai, Guangfu Jin, Zhibin Hu, Shui Wang, Xuechen Wang, Jianwei Qin, et al. “Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.Int J Cancer 118, no. 10 (May 15, 2006): 2554–58. https://doi.org/10.1002/ijc.21652.
Liu, Jiyong, et al. “Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population.Int J Cancer, vol. 118, no. 10, May 2006, pp. 2554–58. Pubmed, doi:10.1002/ijc.21652.
Liu J, Zhai X, Jin G, Hu Z, Wang S, Wang X, Qin J, Gao J, Ma H, Wei Q, Shen H. Functional variants in the promoter of interleukin-1beta are associated with an increased risk of breast cancer: a case-control analysis in a Chinese population. Int J Cancer. 2006 May 15;118(10):2554–2558.

Published In

Int J Cancer

DOI

ISSN

0020-7136

Publication Date

May 15, 2006

Volume

118

Issue

10

Start / End Page

2554 / 2558

Location

United States

Related Subject Headings

  • Risk Factors
  • Promoter Regions, Genetic
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Odds Ratio
  • Middle Aged
  • Interleukin-1
  • Humans
  • Genotype
  • Female