Skip to main content

Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation.

Publication ,  Journal Article
Liao, Z; Liu, H; Swisher, SG; Wang, L; Wu, T-T; Correa, AM; Roth, JA; Cox, JD; Komaki, R; Ajani, JA; Wei, Q
Published in: Int J Radiat Oncol Biol Phys
March 1, 2006

PURPOSE: To test the hypothesis that TS3'UTR polymorphisms predict outcomes in 146 Caucasian patients with esophageal adenocarcinoma treated with preoperative 5-fluorouracil-based chemoradiation. METHODS AND MATERIALS: DNA was extracted from hematoxylin-and-eosin stained histologic slides of normal esophageal or gastric mucosa sections from paraffin blocks of esophagectomy specimens. Genotypes of the TS3'UTR polymorphism were determined by polymerase chain reaction for a 6-bp insertion. The genotype groups (0bp/0bp, 6bp/0bp, and 6bp/6bp) were compared for clinical features and overall survival, recurrence-free-survival, locoregional control (LRC), and distant metastasis control. Multivariable Cox regression analyses were performed to find independent predictors for the stated outcomes. RESULTS: There was a trend of association between 6bp/6bp genotype and a decreased risk of local regional recurrence (hazards ratio = 0.211, 95% confidence interval = 0.041-1.095, p = 0.06) compared with other genotypes. There was a trend that patients with 6bp/6bp genotype had a higher 3-year probability of LRC compared with patients with the other two genotypes combined (p = 0.07); however, the difference was not statistically significant. CONCLUSIONS: The null hypotheses were not rejected in this study, probably owing to small sample size or the single gene examined. Prospective studies with adequate statistical power analyzing a family of genes involved in the 5-fluorouracil metabolism are needed to assess genetic determinants of treatment-related outcomes in esophageal adenocarcinoma.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

March 1, 2006

Volume

64

Issue

3

Start / End Page

700 / 708

Location

United States

Related Subject Headings

  • White People
  • Thymidylate Synthase
  • Survival Analysis
  • Regression Analysis
  • Prospective Studies
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Liao, Z., Liu, H., Swisher, S. G., Wang, L., Wu, T.-T., Correa, A. M., … Wei, Q. (2006). Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation. Int J Radiat Oncol Biol Phys, 64(3), 700–708. https://doi.org/10.1016/j.ijrobp.2005.08.008
Liao, Zhongxing, Hongji Liu, Stephen G. Swisher, Luo Wang, Tsung-Teh Wu, Arlene M. Correa, Jack A. Roth, et al. “Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation.Int J Radiat Oncol Biol Phys 64, no. 3 (March 1, 2006): 700–708. https://doi.org/10.1016/j.ijrobp.2005.08.008.
Liao, Zhongxing, et al. “Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation.Int J Radiat Oncol Biol Phys, vol. 64, no. 3, Mar. 2006, pp. 700–08. Pubmed, doi:10.1016/j.ijrobp.2005.08.008.
Liao Z, Liu H, Swisher SG, Wang L, Wu T-T, Correa AM, Roth JA, Cox JD, Komaki R, Ajani JA, Wei Q. Polymorphism at the 3'-UTR of the thymidylate synthase gene: a potential predictor for outcomes in Caucasian patients with esophageal adenocarcinoma treated with preoperative chemoradiation. Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):700–708.

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

March 1, 2006

Volume

64

Issue

3

Start / End Page

700 / 708

Location

United States

Related Subject Headings

  • White People
  • Thymidylate Synthase
  • Survival Analysis
  • Regression Analysis
  • Prospective Studies
  • Polymorphism, Genetic
  • Oncology & Carcinogenesis
  • Multivariate Analysis
  • Middle Aged
  • Male