The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.
Publication
, Journal Article
McDonald, JM; Dunlap, S; Cogdell, D; Dunmire, V; Wei, Q; Starzinski-Powitz, A; Sawaya, R; Bruner, J; Fuller, GN; Aldape, K; Zhang, W
Published in: Cancer Biol Ther
March 2006
Allelic loss of the short arm of chromosome 1 has been observed frequently in oligodendroglioma (60-80%). We evaluated 177 oligodendroglial tumor samples and defined a consensus region of deletion of approximately 630 kb. This region contains a single gene, SHREW1, which encodes a novel transmembrane protein in adherens junctions. Whereas a mutation was not detected in the coding region of the SHREW1 gene in oligodendrogliomas, restoration of SHREW1 expression resulted in suppression of cell adhesion and migration. Thus, SHREW1 inactivation may play a role in the development of oligodendroglial tumors.
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Published In
Cancer Biol Ther
DOI
ISSN
1538-4047
Publication Date
March 2006
Volume
5
Issue
3
Start / End Page
300 / 304
Location
United States
Related Subject Headings
- Transfection
- Polymerase Chain Reaction
- Oncology & Carcinogenesis
- Oligodendroglioma
- Mutation
- Microsatellite Repeats
- Membrane Proteins
- Humans
- Genes, Tumor Suppressor
- Gene Deletion
Citation
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Chicago
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MLA
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McDonald, J. M., Dunlap, S., Cogdell, D., Dunmire, V., Wei, Q., Starzinski-Powitz, A., … Zhang, W. (2006). The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. Cancer Biol Ther, 5(3), 300–304. https://doi.org/10.4161/cbt.5.3.2391
McDonald, J Matthew, Sarah Dunlap, David Cogdell, Valerie Dunmire, Qingyi Wei, Anna Starzinski-Powitz, Raymond Sawaya, et al. “The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.” Cancer Biol Ther 5, no. 3 (March 2006): 300–304. https://doi.org/10.4161/cbt.5.3.2391.
McDonald JM, Dunlap S, Cogdell D, Dunmire V, Wei Q, Starzinski-Powitz A, et al. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. Cancer Biol Ther. 2006 Mar;5(3):300–4.
McDonald, J. Matthew, et al. “The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration.” Cancer Biol Ther, vol. 5, no. 3, Mar. 2006, pp. 300–04. Pubmed, doi:10.4161/cbt.5.3.2391.
McDonald JM, Dunlap S, Cogdell D, Dunmire V, Wei Q, Starzinski-Powitz A, Sawaya R, Bruner J, Fuller GN, Aldape K, Zhang W. The SHREW1 gene, frequently deleted in oligodendrogliomas, functions to inhibit cell adhesion and migration. Cancer Biol Ther. 2006 Mar;5(3):300–304.
Published In
Cancer Biol Ther
DOI
ISSN
1538-4047
Publication Date
March 2006
Volume
5
Issue
3
Start / End Page
300 / 304
Location
United States
Related Subject Headings
- Transfection
- Polymerase Chain Reaction
- Oncology & Carcinogenesis
- Oligodendroglioma
- Mutation
- Microsatellite Repeats
- Membrane Proteins
- Humans
- Genes, Tumor Suppressor
- Gene Deletion